Journal ArticleDOI
Paediatric cancer in low-income and middle-income countries
Ian Magrath,Eva Steliarova-Foucher,Sidnei Epelman,Raul C. Ribeiro,Mhamed Harif,Chi Kong Li,Rejin Kebudi,Scott D Macfarlane,Scott C. Howard +8 more
TLDR
This work discusses childhood cancer in relation to global development and proposes strategies that could result in improved survival and education of the public, more and better-trained health professionals, strengthened cancer services, locally relevant research, regional hospital networks, international collaboration, and health insurance are all essential components of an enhanced model of care.Abstract:
Summary Patterns of cancer incidence across the world have undergone substantial changes as a result of industrialisation and economic development. However, the economies of most countries remain at an early or intermediate stage of development—these stages are characterised by poverty, too few health-care providers, weak health systems, and poor access to education, modern technology, and health care because of scattered rural populations. Low-income and middle-income countries also have younger populations and therefore a larger proportion of children with cancer than high-income countries. Most of these children die from the disease. Chronic infections, which remain the most common causes of disease-related death in all except high-income countries, can also be major risk factors for childhood cancer in poorer regions. We discuss childhood cancer in relation to global development and propose strategies that could result in improved survival. Education of the public, more and better-trained health professionals, strengthened cancer services, locally relevant research, regional hospital networks, international collaboration, and health insurance are all essential components of an enhanced model of care.read more
Citations
More filters
Book
Cancer and AIDS: Part III: Presentation and Management
TL;DR: In this paper, the authors present, recognition and prevention of cancer and retroviral diseases, and present and manage a disease presentation, recognition, and prevention system for cancer patients.
Journal ArticleDOI
Pathology-Based Research in Africa.
Maria P. Lemos,Terrie E. Taylor,Suzanne M. McGoldrick,Malcolm E. Molyneux,Manoj Menon,Steve Kussick,Nonhlanhla N. Mkhize,Neil A. Martinson,Andrea Stritmatter,Julie Randolph-Habecker +9 more
TL;DR: 3 different research efforts: fatal malaria in Malawi, mucosal immunity to HIV in South Africa, and cancer research in Uganda are reviewed, what unifies them is the use of pathology-based approaches to answer vital questions, such as physiology, pathogenesis, predictors of clinical course, and diagnostic testing schemes.
Journal ArticleDOI
Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study
TL;DR: The COVID-19 pandemic has affected paediatric oncology service provision worldwide and disproportionately affected patients in low-income and middle-income countries, highlighting and compounding existing disparities in healthcare systems globally that need addressing urgently.
Book ChapterDOI
Early Hematopoietic Differentiation in Acute Lymphoblastic Leukemia: The Interplay Between Leukemia-Initiating Cells and Abnormal Bone Marrow Microenvironment
Armando Vilchis-Ordoñez,Elisa Dorantes-Acosta,Eduardo Vadillo,Briceida López-Martínez,Rosana Pelayo +4 more
TL;DR: By unraveling the role of leukemic precursor cells in the initiation of local inflammatory processes leading to hematopoietic instability, additional mechanisms co-participating in the etiology and maintenance of this pathological condition are learned.
Journal ArticleDOI
Use of Fungal Diagnostics and Therapy in Pediatric Cancer Patients in Resource-Limited Settings
TL;DR: This review presents relevant, up-to-date information about the most common opportunistic and endemic fungal diseases among children with cancer, their geographic distribution, and recommended diagnostics and treatment.
References
More filters
Journal ArticleDOI
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
Journal ArticleDOI
Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study
Eva Steliarova-Foucher,Charles A. Stiller,Peter Kaatsch,Franco Berrino,Jan Willem Coebergh,Brigitte Lacour,Max Perkin +6 more
TL;DR: There is clear evidence of an increase of cancer incidence in childhood and adolescence during the past decades, and of an acceleration of this trend, as well as providing an indicator of progress of public-health policy in Europe.
Journal ArticleDOI
Aetiology of acute leukaemia
TL;DR: Questions about ionising radiation, as well as how chemical agents, including therapeutic substances, might contribute to leukaemogenesis, are discussed in this last article in the leukaemia series.
Journal ArticleDOI
The quest for universal health coverage: achieving social protection for all in Mexico
Felicia Marie Knaul,Eduardo González-Pier,Octavio Gómez-Dantés,David García-Junco,Héctor Arreola-Ornelas,Mariana Barraza-Lloréns,Rosa Carolina Sandoval,Francisco Félix Caballero,Mauricio Hernández-Ávila,Mercedes Juan,David Kershenobich,Gustavo Nigenda,Enrique Ruelas,Jaime Sepúlveda,Roberto Tapia,Guillermo Soberón,Salomón Chertorivski,Julio Frenk +17 more
TL;DR: Evidence indicates that Seguro Popular is improving access to health services and reducing the prevalence of catastrophic and impoverishing health expenditures, especially for the poor, and recent studies also show improvement in effective coverage.
Journal ArticleDOI
Characteristics of clinical trials registered in ClinicalTrials.gov, 2007-2010.
Robert M. Califf,Deborah A. Zarin,Judith M. Kramer,Rachel E. Sherman,Laura H. Aberle,Asba Tasneem +5 more
TL;DR: In this article, the authors examined fundamental characteristics of interventional clinical trials registered in the ClinicalTrialsgov database and identified the three clinical specialties (cardiovascular, mental health and oncology) that together encompass the largest number of disability-adjusted life-years lost in the United States.
Related Papers (5)
International Classification of Childhood Cancer, third edition
International incidence of childhood cancer, 2001-10 a population-based registry study
Eva Steliarova-Foucher,Murielle Colombet,Lynn A. G. Ries,Florencia Moreno,Anastasia Dolya,Freddie Bray,Peter Hesseling,Hee Young Shin,Charles A. Stiller,S Bouzbid,M. Hamdi-Cherif,A Hablas,E Chirpaz,Nathan Buziba,GC Chesumbai,Shyam Manraj,D Reynders,Henry Wabinga,Eric Chokunonga,F. C. Moreno,Carlos Anselmo Lima,C Asturian Laporte,JC de Oliveira,JA Pontes de Aquino,SM Vargas Gallagher,Claudia Uribe,Luis Eduardo Bravo,M C Yépez Chamorro,G Torres Alvarado,Y H Galán Alvarez,FC Martinez Reyes,JC Castillo Calvas,M Mendoza Alava,P Cueva Ayala,Barrie Hanchard,Arturo Fajardo-Gutiérrez,DE Zavala Zegarra,Enrique Barrios,C Nikiforuk,Ryan Woods,D Turner,Michael F. MacIntyre,A Corriveau,T Navaneelan,C Bertrand,H Stuart-Panko,RJ Wilson,C Kosary,X Shen,J.T. Brockhouse,Ga Yee,TC Mitchell,K Snipes,Dennis P. West,C Rao,S.W. Bolick,R. Rycroft,Lloyd Mueller,Y Zheng,K Dosch,Heath Brown,A Vargas,G M Levin,R Bayakly,Christopher J. Johnson,T Shen,L P Ruppert,Charles F. Lynch,SM Lai,Thomas C. Tucker,XC Wu,M Schwenn,K Stern,S.T. Gershman,Glenn Copeland,S Bushhouse,DB Rogers,J Jackson Thompson,D Lemons,S Frederick,JA Harris,B Riddle,Antoinette M. Stroup,Charles L. Wiggins,Maria J. Schymura,L K Giljahn,A Sheikh,Sara Schubert,W Aldinger,JP Fulton,M.A. Whiteside,Leticia Nogueira,Christopher Sweeney,A T Johnson,Janet Martin,S Farley,D.G. Harrelson,R Malicki,JR Espinoza,Brenda Y. Hernandez,N Abulfateh,N Wang,Rkc Ngan,K B Lingegowda,Rajaraman Swaminathan,Shravani Koyande,Barbara G. Silverman,K Ozasa,S Kanemura,M Soda,Isao Miyashiro,Ai Shibata,Omar Nimri,Young-Joo Won,CH Kim,NS Hong,HS Nam,S Kweon,Woo Chul Kim,JS Huh,Kyu-Won Jung,Ci Yoo,Amani El-Basmy,Adriano V. Laudico,Lumague,H AlMutlag,Rangsiya Buasom,Songpol Srisukho,J Tanabodee,Surapon Wiangnon,Donsuk Pongnikorn,Hutcha Sriplung,O Dirican,Sultan Eser,M Le Hoang,Monika Hackl,Anna Zborovskaya,Nadya Dimitrova,Zdravka Valerianova,M. Sekerija,Pavlos Pavlou,M Dušek,Margit Mägi,Jacqueline Clavel,Brigitte Lacour,A.V. Guizard,Véronique Bouvier,Xavier Troussard,Anne-Sophie Woronoff,Brigitte Trétarre,M. Colonna,Florence Molinié,Simona Bara,Michel Velten,E Marrer,O Ganry,Pascale Grosclaude,Peter Kaatsch,Sylke Ruth Zeissig,Bernd Holleczek,Alexander Katalinic,Zsuzsanna Jakab,H Birgisson,Paul M. Walsh,Lucia Mangone,Franco Merletti,M Magoni,Stefano Ferretti,Diego Serraino,Gianbattista Spagnoli,M Fusco,Maria Michiara,R. Tumino,Fabio Falcini,Flavio Sensi,F Tisano,Silvano Piffer,Fabrizio Stracci,Giovanna Tagliabue,Giedre Smailyte,Dominic Agius,Otto Visser,Giske Ursin,J.A. Didkowska,Maciej Trojanowski,U Wojciechowska,G. Forjaz de Lacerda,MA Silva,J Laranja Pontes,A da Costa Miranda,E Kaiserova,M Primic Žakelj,Rafael Peris-Bonet,ML Vicente Raneda,E Almar Marqués,JR Quirós Garcia,M Ramos Monserrat,M Errezola Saizar,A Alemán Herrera,J.M. Díaz García,Rafael Marcos-Gragera,María-José Sánchez-Pérez,E Ardanaz Aicua,Jaume Galceran,Åsa Klint,Claudia E. Kuehni,C. Bouchardy,Fabio Levi,Andrea Bordoni,Isabelle Konzelmann,Sabine Rohrmann,CA Stiller,Anna Gavin,David H. Brewster,H Phung,S Rushton,Steven Guthridge,Joanne F. Aitken,K D'Onise,A Venn,H Farrugian,T. Threlfall,S Laumond,L Yen Kai Sun,J Hendrix,K Ballantine,M Colombet,A Dolya,E. Masuyer,E Steliarova-Foucher +229 more