Journal ArticleDOI
Paediatric cancer in low-income and middle-income countries
Ian Magrath,Eva Steliarova-Foucher,Sidnei Epelman,Raul C. Ribeiro,Mhamed Harif,Chi Kong Li,Rejin Kebudi,Scott D Macfarlane,Scott C. Howard +8 more
TLDR
This work discusses childhood cancer in relation to global development and proposes strategies that could result in improved survival and education of the public, more and better-trained health professionals, strengthened cancer services, locally relevant research, regional hospital networks, international collaboration, and health insurance are all essential components of an enhanced model of care.Abstract:
Summary Patterns of cancer incidence across the world have undergone substantial changes as a result of industrialisation and economic development. However, the economies of most countries remain at an early or intermediate stage of development—these stages are characterised by poverty, too few health-care providers, weak health systems, and poor access to education, modern technology, and health care because of scattered rural populations. Low-income and middle-income countries also have younger populations and therefore a larger proportion of children with cancer than high-income countries. Most of these children die from the disease. Chronic infections, which remain the most common causes of disease-related death in all except high-income countries, can also be major risk factors for childhood cancer in poorer regions. We discuss childhood cancer in relation to global development and propose strategies that could result in improved survival. Education of the public, more and better-trained health professionals, strengthened cancer services, locally relevant research, regional hospital networks, international collaboration, and health insurance are all essential components of an enhanced model of care.read more
Citations
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Epidemiology of childhood and adolescent cancer in Bangladesh, 2001–2014
Mohammad Sorowar Hossain,Mamtaz Begum,Mahmuduzzaman Mian,Shameema Ferdous,Shahinur Kabir,Humayun Kabir Sarker,Sabina Karim,Salma Choudhury,Asaduzzaman Khan,Zohora Jameela Khan,Henrike E. Karim-Kos +10 more
TL;DR: Cancer incidences in Bangladesh were lower than expected most likely due to a low level of awareness about cancer among clinicians and the population, inadequate access to health care, lack of diagnostic equipment and incomplete recording of cases.
Journal ArticleDOI
Characterising the epigenome as a key component of the fetal exposome in evaluating in utero exposures and childhood cancer risk
TL;DR: New opportunities in the current age of 'omics' technologies for studies with prospective design and associated biospecimens that represent exciting potential for characterising the epigenome as a key component of the fetal exposome and for understanding causal pathways and robust predictors of cancer risk and associated environmental determinants during in utero life are discussed.
Journal ArticleDOI
Socioeconomic status and global variations in the incidence of neuroblastoma: call for support of population-based cancer registries in low-middle-income countries.
Junne Kamihara,Clement Ma,Soad Fuentes Alabi,Claudia Garrido,A. Lindsay Frazier,Carlos Rodriguez-Galindo,Manuela Orjuela +6 more
TL;DR: Investigating the relationship between the incidence of embryonal tumors and human development index on a global scale finds increasing incidence of neuroblastoma correlates significantly with an increasing index of human development, with greater incidence among countries with high socioeconomic development.
Journal ArticleDOI
Poverty and the risk of leukemia and cancer in the central nervous system in children: A cohort study in a high-income country:
TL;DR: Being born into a household of low family income the first 2 years of life was found to be a risk factor for development of lymphoid leukemia.
Journal ArticleDOI
Increased incidence and disparity of diagnosis of retinoblastoma patients in Guatemala.
Michael Dean,Giovana Bendfeldt,Hong Lou,Verónica Girón,Claudia Garrido,Patricia Valverde,Margarita Barnoya,Mauricio Castellanos,Silvia Jiménez-Morales,Sandra Luna-Fineman +9 more
TL;DR: Analysis of 327 consecutive cases at a pediatric referral hospital of Guatemala reveals that retinoblastoma accounts for 9.4% of all cancers and the estimated incidence is 7.0 cases/million children, higher than the United States or Europe.
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