Journal ArticleDOI
Paediatric cancer in low-income and middle-income countries
Ian Magrath,Eva Steliarova-Foucher,Sidnei Epelman,Raul C. Ribeiro,Mhamed Harif,Chi Kong Li,Rejin Kebudi,Scott D Macfarlane,Scott C. Howard +8 more
TLDR
This work discusses childhood cancer in relation to global development and proposes strategies that could result in improved survival and education of the public, more and better-trained health professionals, strengthened cancer services, locally relevant research, regional hospital networks, international collaboration, and health insurance are all essential components of an enhanced model of care.Abstract:
Summary Patterns of cancer incidence across the world have undergone substantial changes as a result of industrialisation and economic development. However, the economies of most countries remain at an early or intermediate stage of development—these stages are characterised by poverty, too few health-care providers, weak health systems, and poor access to education, modern technology, and health care because of scattered rural populations. Low-income and middle-income countries also have younger populations and therefore a larger proportion of children with cancer than high-income countries. Most of these children die from the disease. Chronic infections, which remain the most common causes of disease-related death in all except high-income countries, can also be major risk factors for childhood cancer in poorer regions. We discuss childhood cancer in relation to global development and propose strategies that could result in improved survival. Education of the public, more and better-trained health professionals, strengthened cancer services, locally relevant research, regional hospital networks, international collaboration, and health insurance are all essential components of an enhanced model of care.read more
Citations
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Position paper: Challenges and specific strategies for constitutional mismatch repair deficiency syndrome in low-resource settings.
Rejin Kebudi,Nisreen Amayiri,Malak Abedalthagafi,Asim Noor Rana,Salman Kirmani,Naureen Musthaq,Zakiya Al Lamki,Jamila El Houdzi,Hulya Yazici,Shahenda El‐Naggar,Melissa Edwards,Vanessa Bianchi,Carol Durno,Uri Tabori,Eric Bouffet +14 more
TL;DR: It is important to provide a summary of the current situation, and to highlight the necessity of increasing awareness, diagnostic criteria, and surveillance to improve survival for patients and family members.
Journal ArticleDOI
Highlights from the 1st Latin American meeting on metronomic chemotherapy and drug repositioning in oncology, 27–28 May, 2016, Rosario, Argentina
Adriana Rose,Nicolas André,Viviana R. Rozados,Leandro E. Mainetti,Mauricio Ariel Menacho Márquez,María José Rico,Paula Schaiquevich,Milena Villarroel,Lauro José Gregianin,Jaume Mora Graupera,Wendy Gomez Garcia,Sidnei Epelman,Carlos M. Alasino,Daniel F. Alonso,Guillermo L. Chantada,Graciela Scharovsky +15 more
TL;DR: It was shown that metronomics offers treatments, which, whether they are combined or not with the standard therapeutic approaches, are not only effective but also minimally toxic, with the consequent improvement of the patient’s quality of life, and inexpensive, a feature very important in low resource clinical settings.
Book ChapterDOI
Pediatric Oncology Nursing Research in Low- and Middle-Income Countries
TL;DR: The nursing research evidence presented here will begin to inform personalized and precision health in L&MIC to ensure that care is culturally acceptable and considers the environment, nursing practice, nursing science, family, lifestyle behaviors, and response to disease and treatment of this large patient population.
Journal ArticleDOI
Expression of ZNF695 Transcript Variants in Childhood B-Cell Acute Lymphoblastic Leukemia.
Ricardo Valentin de la Rosa,Vanessa Villegas-Ruíz,Marcela Concepción Caballero-Palacios,Eleazar Israel Pérez-López,Chiharu Murata,Martha Zapata-Tarres,Rocío Cárdenas-Cardós,Rogelio Paredes-Aguilera,Roberto Rivera-Luna,Sergio Juárez-Méndez +9 more
TL;DR: It is observed that long noncoding RNA ZNF695 expression predicted survival rates and the co-expression of coding and long nonCoding RNA.
Journal ArticleDOI
Investigating Wilms’ Tumours Worldwide: A Report of the OxPLORE Collaboration—A Cross-Sectional Observational Study
Kathryn Ford,S Gunawardana,Emery Manirambona,G S Philipoh,B Mukama,A Kanyamuhunga,Peter Cartledge,Peter Cartledge,M J Nyoni,D Mwaipaya,J Mpwaga,Z Bokhary,T Scanlan,T Heinsohn,H Hathaway,Roshni Mansfield,S Wilson,Kokila Lakhoo +17 more
TL;DR: This study demonstrates novel research methodology involving medical students collaborating across the global south and global north and comparison of outcomes advocates, on an institutional level, for development in access to services and multidisciplinary treatment of Wilms’ tumour.
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