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Journal ArticleDOI

Parathyroid hormone, vitamin D, renal dysfunction, and cardiovascular disease: dependent or independent risk factors?

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TLDR
Elevated PTH is associated with a greater prevalence and incidence of CV risk factors and predicts a greater likelihood of prevalent and incident disease, including mortality, and persists when adjusted for 25(OH)D, renal function, and standard risk factors.
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This article is published in American Heart Journal.The article was published on 2011-08-01. It has received 130 citations till now. The article focuses on the topics: Hyperparathyroidism & Parathyroid hormone.

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Citations
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Journal ArticleDOI

Effects of Age and Serum 25-OH-Vitamin D on Serum Parathyroid Hormone Levels

TL;DR: Serum 25-OHD was below the recent Institute of Medicine sufficiency guidance of 20 ng/ml in 27% (85,000) of the subjects and 40 and 51% of subjects had biochemical hyperparathyroidism (PTH > 65 pg/ml).
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Parathyroid hormone and cardiovascular disease events: A systematic review and meta-analysis of prospective studies.

TL;DR: The meta-analysis indicates that higher PTH concentrations are associated with increased risk of CVD events, and specifically in whites with a mean age between 55 and 75 years.
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Elevated Parathyroid Hormone, But Not Vitamin D Deficiency, Is Associated With Increased Risk of Heart Failure in Older Men With and Without Cardiovascular Disease

TL;DR: Elevated PTH, but not 25-hydroxyvitamin D or other markers of mineral metabolism, is associated with increased risk of HF in both older men with and without myocardial infarction/stroke.
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Coronary Microvascular Dysfunction Induced by Primary Hyperparathyroidism is Restored After Parathyroidectomy

TL;DR: PHPT patients have coronary microvascular dysfunction that is completely restored after parathyroidectomy, suggesting a crucial role of the hormone in explaining the increased cardiovascular risk in PHPT.
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The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload

TL;DR: Treatment with the selective VDR activator paricalcitol reduces myocardial fibrosis and preserves diastolic LV function due to pressure overload in a mouse model.
References
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Journal ArticleDOI

Vitamin D Deficiency

TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
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Comparison of Mortality in All Patients on Dialysis, Patients on Dialysis Awaiting Transplantation, and Recipients of a First Cadaveric Transplant

TL;DR: In this paper, the authors conducted a longitudinal study of mortality in 228,552 patients who were receiving long-term dialysis for end-stage renal disease, and 46,164 were placed on a waiting list for transplantation, 23,275 of whom received a first cadaveric transplant between 1991 and 1997.
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Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?

TL;DR: A growing body of data suggests that low 25-hydroxyvitamin D levels may adversely affect cardiovascular health as discussed by the authors, and large randomized controlled trials are needed to firmly establish the relevance of vitamin D status to cardiovascular health.
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Relation of Vitamin D Deficiency to Cardiovascular Risk Factors, Disease Status, and Incident Events in a General Healthcare Population

TL;DR: A high prevalence of vitamin D deficiency in the general healthcare population and an association between vitamin D levels and prevalent and incident CV risk factors and outcomes are confirmed, lending strong support to the hypothesis that vitamin D might play a primary role in CV risk Factors and disease.
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