Paternal factors contributing to embryo quality
Stacy Colaco,Denny Sakkas +1 more
TLDR
It is proposed that careful assessment of spermatozoal parameters is essential to achieve embryo development and a healthy live birth and the need for more research and the development of standardized protocols to assess the role of sperm factors affecting embryo quality.Abstract:
Advancing maternal and paternal age leads to a decrease in fertility, and hence, many infertile couples opt for assisted reproductive technologies [ART] to achieve biological parenthood. One of the key determinants of achieving a live outcome of ART, embryo quality, depends on both the quality of the oocyte and sperm that have created the embryo. Several studies have explored the effect of oocyte parameters on embryo quality, but the effects of sperm quality on the embryo have not been comprehensively evaluated. In this review, we assess the effect of various genetic factors of paternal origin on the quality and development of the embryo. The effects of sperm aneuploidy, sperm chromatin structure, deoxyribonucleic acid [DNA] fragmentation, role of protamines and histones, sperm epigenetic profile, and Y chromosome microdeletions were explored and found to negatively affect embryo quality. We propose that careful assessment of spermatozoal parameters is essential to achieve embryo development and a healthy live birth. However, the heterogeneity in test results and the different approaches of assessing a single sperm parameter highlight the need for more research and the development of standardized protocols to assess the role of sperm factors affecting embryo quality.read more
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Periconceptional environment and the developmental origins of disease
TL;DR: Four types of environmental exposure shown to modify periconceptional reproduction and offspring development and health: maternal overnutrition and obesity; maternal undernutrition; paternal diet and health; and assisted reproductive technology are focused on.
Journal ArticleDOI
Does the transfer of a poor quality embryo together with a good quality embryo affect the In Vitro Fertilization (IVF) outcome
Eliana Muskin Wintner,Eliana Muskin Wintner,Anat Hershko-Klement,Anat Hershko-Klement,Keren Tzadikevitch,Keren Tzadikevitch,Yehudith Ghetler,Yehudith Ghetler,Ofer Gonen,Ofer Gonen,Oren Wintner,Oren Wintner,Adrian Shulman,Adrian Shulman,Amir Wiser,Amir Wiser +15 more
TL;DR: A poor quality embryo does not negatively affect a good quality embryo, when transferred together in a double embryo transfer.
Journal ArticleDOI
Preimplantation Genetic Testing: Where We Are Today.
Ermanno Greco,Katarzyna Litwicka,Maria Giulia Minasi,Elisabetta Cursio,Pier Francesco Greco,Paolo Barillari +5 more
TL;DR: The preimplantation genetic testing is a valid technique to evaluated embryo euploidy and mosaicism before transfer and to improve clinical outcomes in terms of embryo implantation, clinical pregnancy, and live birth rates.
Journal ArticleDOI
Sperm DNA damage causes genomic instability in early embryonic development
Sjors Middelkamp,Helena T.A. van Tol,Diana C.J. Spierings,Sander Boymans,Victor Guryev,Bernard A.J. Roelen,Peter M. Lansdorp,Peter M. Lansdorp,Peter M. Lansdorp,Edwin Cuppen,Ewart W. Kuijk +10 more
TL;DR: The consequences of sperm DNA damage on the embryonic genome by single-cell whole-genome sequencing of individual blastomeres from bovine embryos produced with sperm damaged by γ-radiation are examined.
Journal ArticleDOI
Consequences of Y chromosome microdeletions beyond male infertility.
Stacy Colaco,Deepak Modi +1 more
TL;DR: Observations suggest that the azoospermia factor genes may have functions beyond regulation of fertility, and this information will provide a different perspective in the area of androgenetics and have implications in devising strategies for maintaining the overall well-being of infertile males.
References
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Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte
TL;DR: Intracytoplasmic sperm injection is used to treat couples with infertility because of severely impaired sperm characteristics, and in whom IVF and SUZI had failed.
Journal ArticleDOI
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Journal ArticleDOI
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TL;DR: The male-specific region of the Y chromosome, the MSY, differentiates the sexes and comprises 95% of the chromosome's length, and is a mosaic of heterochromatic sequences and three classes of euchromatics sequences: X-transposed, X-degenerate and ampliconic.
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Human gene expression first occurs between the four- and eight-cell stages of preimplantation development
TL;DR: Changes in the pattern of polypeptides synthesized during the pre-implantation stages of human development are described, and it is demonstrated that some of the major qualitative changes which occur between the four- and eight-cell stages are dependent on transcription.