Journal ArticleDOI
PEG drugs: an overview
TLDR
This recent resuscitation of small organic molecule delivery by high molecular weight PEG conjugates was founded on meaningful in vivo testing using established tumor models, and has led to a clinical candidate.About:
This article is published in Journal of Controlled Release.The article was published on 2001-07-06. It has received 378 citations till now. The article focuses on the topics: PEG ratio.read more
Citations
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Journal ArticleDOI
Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies.
TL;DR: This review covers the principles, advantages, and drawbacks of passive and active targeting based on various polymer and magnetic iron oxide nanoparticle carriers with drug attached by both covalent and noncovalent pathways.
Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TL;DR: Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.
Journal ArticleDOI
The Impact of PEGylation on Biological Therapies
Francesco M. Veronese,Anna Mero +1 more
TL;DR: The chemical procedures and the conditions that have been used thus far to achieve PEGylation of biomedical molecules are reviewed and the importance of structure and size of P EGs, as well as the behavior of linear and branched PEGs are discussed.
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Dendrimers as carriers for delivery of chemotherapeutic agents.
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Polymer-drug conjugates: Progress in polymeric prodrugs
Jayant Khandare,Tamara Minko +1 more
TL;DR: The current synthetic advances in polymer-conjugation with different bioactive components of clinical importance are discussed and the strategies for reduction of steric hindrance and increase in reactivity of the polymers, drugs and bioactive agents are described.
References
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Journal ArticleDOI
Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.
TL;DR: The modified bovine serum albumins showed substantial changes in properties, such as solubility, electrophoretic mobility in acrylamide gel, ion exchange chromatography, and sedimentation, as compared with the unmodified protein.
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Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice
TL;DR: The results of pharmacokinetic analysis suggested that small PEG tended to freely translocate from the circulation to extravascular tissues and to return to the blood circulation again by diffusion, whereas large PEG translocated more slowly to extraVascular tissues.
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SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy.
TL;DR: The clinical possibilities for SMANCS are discussed, including the suggestion that angiotensin II-induced hypertension has clinical potential in improving the selective delivery of macromolecular drugs (i.e. SMAN CS) to tumors.