Journal ArticleDOI
Pegylated poly(lactide) and poly(lactide-co-glycolide) nanoparticles: preparation, properties and possible applications in drug delivery.
TLDR
The ability of the PLA-Peg and PLGA-PEG nanoparticles to evade rapid phagocytocis has extended the range of sites within the body that the nanoparticles can reach, which has significant implications with regard to their application in controlled drug delivery and targeting.Abstract:
The preparation, properties and potential applications in drug delivery of biocompatible and biodegradable PLA-PEG and PLGA-PEG nanoparticles are discussed. PLA-PEG and PLGA-PEG nanoparticles have been produced by emulsification-solvent evaporation, solvent displacement and salting out methods. The nanoparticles can be stored as freeze-dried powders, but an adequate amount of a suitable lyoprotectant should be added prior lyophilisation to prevent nanoparticle aggregation and retain nanoparticle redispersibility. The nanoparticles have a core-shell structure with a PLA core and a PEG coating. Their basic colloidal properties and degradation depend on copolymer composition. The PLA-PEG and PLGA-PEG nanoparticles exhibit prolonged blood circulation following intravenous administration to animals. The composition of the nanoparticles determine their biodistribution properties, probably through its effects on the effectiveness of the PEG steric barrier and the size of the nanoparticles. The ability of the PLA-PEG and PLGA-PEG nanoparticles to evade rapid phagocytocis has extended the range of sites within the body that the nanoparticles can reach, which has significant implications with regard to their application in controlled drug delivery and targeting. The PLA-PEG and PLGA-PEG nanoparticles can be loaded with a variety of bioactive agents achieving satisfactory loading, especially in the case of hydrophobic drugs. The nanoparticles have been investigated for the treatment of infectious diseases and cancer, the intravenous and mucosal delivery of proteins, and oligonucleotide and gene delivery. The results have been encouraging and PLA-PEG and PLGA-PEG nanoparticle formulations, improving the therapeutic potential of both established and new drugs, may be expected to be available in the near future.read more
Citations
More filters
Journal ArticleDOI
Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile
Jeffrey S. Hrkach,Daniel D. Von Hoff,Mir Mukkaram Ali,Elizaveta Andrianova,Jason Auer,Tarikh Christopher Campbell,David De Witt,Michael Figa,Maria Figueiredo,Allen Horhota,Susan Low,Kevin McDonnell,Erick Peeke,Beadle Retnarajan,Abhimanyu Sabnis,Edward Schnipper,Jeffrey J. Song,Young-Ho Song,Jason Summa,Douglas Tompsett,Greg Troiano,Tina Van Geen Hoven,James Wright,Patricia LoRusso,Philip W. Kantoff,Neil H. Bander,Christopher Sweeney,Omid C. Farokhzad,Robert Langer,Stephen E. Zale +29 more
TL;DR: Developing and clinical translation of a targeted polymeric nanoparticle (TNP) containing the chemotherapeutic docetaxel (DTXL) for the treatment of patients with solid tumors and initial clinical data indicated that DTXL-TNP displays a pharmacological profile differentiated from sb-DTXL.
Journal ArticleDOI
Methods for the preparation and manufacture of polymeric nanoparticles.
TL;DR: This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules and presents the most recent innovations and progresses obtained over the last decade.
Journal ArticleDOI
Microfluidic Platform for Controlled Synthesis of Polymeric Nanoparticles
Rohit Karnik,Frank X. Gu,Pamela Basto,Christopher Cannizzaro,Lindsey Dean,William Kyei-Manu,Robert Langer,Omid C. Farokhzad +7 more
TL;DR: This work used rapid and tunable mixing through hydrodynamic flow focusing in microfluidic channels to control nanoprecipitation of poly(lactic- co-glycolic acid)- b-poly(ethylene glycol) diblock copolymers as a model polymeric biomaterial for drug delivery.
Journal ArticleDOI
Current advances in research and clinical applications of PLGA-based nanotechnology
Jian-Ming Lü,Xinwen Wang,Christian Marin-Muller,Hao Wang,Peter H. Lin,Qizhi Yao,Changyi Chen +6 more
TL;DR: More recent successes of applying PLGA-based nanotechnologies and tools in medicine-related applications are presented and the possible mechanisms, diagnosis and treatment effects of PLGA preparations and devices are focused on.
Journal ArticleDOI
Synthesis and characterization of PLGA nanoparticles
TL;DR: The aim of this review is to clearly, quantitatively and comprehensively describe the top–down synthesis techniques available for PLGA nanoparticle formation, as well as the techniques commonly used for nanoparticle characterization.