Journal ArticleDOI
Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research
TLDR
In this article, a percutaneous needle biopsy of skeletal muscle in Physiological and Clinical Research is described, and the authors present a detailed discussion of the procedure and the results.Abstract:
(1975). Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research. Scandinavian Journal of Clinical and Laboratory Investigation: Vol. 35, No. 7, pp. 609-616.read more
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Journal ArticleDOI
Tricarboxylic acid cycle intermediate pool size and estimated cycle flux in human muscle during exercise
TL;DR: It is suggested that the increase in SigmaTCAI during exercise may primarily reflect an imbalance between the rate of pyruvate production and its rate of oxidation in the TCA cycle.
Journal ArticleDOI
Association of Interleukin-6 Signalling with the Muscle Stem Cell Response Following Muscle-Lengthening Contractions in Humans
Bryon R. McKay,Michael De Lisio,Adam P. W. Johnston,Ciara E. O'Reilly,Stuart M. Phillips,Mark A. Tarnopolsky,Gianni Parise +6 more
TL;DR: It is shown that IL-6 is an important signaling molecule associated with the SC response to acute muscle-lengthening contractions in humans, evidenced by increased Pax7+/PCNA+ cell number in the early stages of the time-course.
Journal ArticleDOI
IL-6 induced STAT3 signalling is associated with the proliferation of human muscle satellite cells following acute muscle damage
Kyle G. Toth,Bryon R. McKay,Michael De Lisio,Jonathon P. Little,Mark A. Tarnopolsky,Gianni Parise +5 more
TL;DR: It is demonstrated that IL-6 induction ofSTAT3 signaling occurred exclusively in the nuclei of SCs in response to MLC, and an increase in the number of cMyc+ SCs indicated that human SCs were induced to proliferate under the control of STAT3 signaling.
Journal ArticleDOI
Influence of Gender, Obesity, and Muscle Lipase Activity on Intramyocellular Lipids in Sedentary Individuals
Cedric Moro,Jose E. Galgani,LanChi Luu,Magdalena Pasarica,Aline Mairal,Aline Mairal,Sudip Bajpeyi,Gerd Schmitz,Dominique Langin,Dominique Langin,Gerhard Liebisch,Steven R. Smith +11 more
TL;DR: The data suggest that intramyocellular DAG is an independent predictor of insulin resistance in humans and that its levels correlate with lipolytic enzymes activity in skeletal muscle but not with markers of adiposity.
Journal ArticleDOI
McArdle disease: what do neurologists need to know?
Alejandro Lucia,Gisela Nogales-Gadea,Margarita Pérez,Miguel A. Martín,Antoni L. Andreu,Joaquín Arenas +5 more
TL;DR: The topics covered include diagnostic tools— for example, molecular genetic diagnosis, the classic ischemic forearm test and the so-called 'second wind' phenomenon—and current therapeutic options—for example, a carbohydrate-rich diet and carbohydrate ingestion shortly before strenuous exercise, in combination with medically supervised aerobic training of low to moderate intensity.
References
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Journal ArticleDOI
Diet, Muscle Glycogen and Physical Performance
TL;DR: It has been shown that the glycogen content and, consequently, the long-term work capacity can be appreciably varied by instituting different diets after glycogen depletion.
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Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values.
TL;DR: Variation in muscle content of ATP, ATP + ADP + AMP, phosphorylcreatine (PC), creatine (Cr), PC + Cr, and glycogen, between legs, between sites on the same muscle, or as a result of error introduced during analysis, was small compared with the between-individuals variance.
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Intracellular free amino acid concentration in human muscle tissue.
Journal ArticleDOI
Selective glycogen depletion pattern in human muscle fibres after exercise of varying intensity and at varying pedalling rates
TL;DR: Glycogen depletion pattern in human skeletal muscle fibres was studied after bicycle exercise of varying intensity performed at different pedalling rates.
Journal ArticleDOI
Muscle Glycogen Synthesis after Exercise : an Enhancing Factor localized to the Muscle Cells in Man
Jonas Bergström,Eric Hultman +1 more
TL;DR: Goldstein1 has shown that a humoral factor, which decreases the blood glucose concentration, is released during exercise and it is known that the insulin requirement decreases in diabetic subjects during exercise.