Journal ArticleDOI
Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research
TLDR
In this article, a percutaneous needle biopsy of skeletal muscle in Physiological and Clinical Research is described, and the authors present a detailed discussion of the procedure and the results.Abstract:
(1975). Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research. Scandinavian Journal of Clinical and Laboratory Investigation: Vol. 35, No. 7, pp. 609-616.read more
Citations
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Journal ArticleDOI
Role of adiponectin in human skeletal muscle bioenergetics.
Anthony E. Civitarese,Barbara Ukropcova,Stacy Carling,Matthew W. Hulver,Ralph A. DeFronzo,Lawrence J. Mandarino,Lawrence J. Mandarino,Eric Ravussin,Steve R. Smith +8 more
TL;DR: It is reported that adiponectin signaling regulates mitochondrial bioenergetics in skeletal muscle and defines a skeletal muscle pathway by which adip onectin increases mitochondrial number and function and exerts antidiabetic effects.
Journal ArticleDOI
Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes.
Luc J. C. van Loon,René Koopman,Ralph J. F. Manders,Walter van der Weegen,Gerrit Van Kranenburg,Hans A. Keizer +5 more
TL;DR: It is concluded that elevated IMCL deposits are unlikely to be directly responsible for inducing insulin resistance, and IMCL contents can be substantially greater in trained endurance athletes compared with overweight and/or type 2 diabetes patients.
Journal ArticleDOI
Substantial skeletal muscle loss occurs during only 5 days of disuse.
Benjamin T. Wall,Marlou L. Dirks,Tim Snijders,Joan M. G. Senden,John Dolmans,L.J.C. van Loon +5 more
TL;DR: This work assessed the impact of 5 and 14 days of disuse on skeletal muscle mass, strength and associated intramuscular molecular signalling responses.
Journal ArticleDOI
Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat
Raffaele Teperino,Sabine Amann,Martina Bayer,Sean L. McGee,Andrea Loipetzberger,Timothy Connor,Carsten Jaeger,Bernd Kammerer,Lilli Winter,Gerhard Wiche,Kevin Dalgaard,Madhan Selvaraj,Michael Gaster,Robert S. Lee-Young,Mark A. Febbraio,Claude Knauf,Patrice D. Cani,Fritz Aberger,Josef M. Penninger,J. Andrew Pospisilik,Harald Esterbauer +20 more
TL;DR: It is shown that hedgehog signaling rewires cellular metabolism and is identified a cilium-dependent Smo-Ca(2+)-Ampk axis that triggers rapid Warburg-like metabolic reprogramming within minutes of activation and is required for proper metabolic selectivity and flexibility.
Journal ArticleDOI
"Semi-open" muscle biopsy technique. A simple outpatient procedure.
TL;DR: An easy and safe method for muscle biopsy is described that combines the advantage of the “open‐surgical” method‐sufficient quantity of material‐with the advantages of the needle methods‐easy to perform, not incapacitating and only slightly uncomfortable for the patient.
References
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Journal ArticleDOI
Diet, Muscle Glycogen and Physical Performance
TL;DR: It has been shown that the glycogen content and, consequently, the long-term work capacity can be appreciably varied by instituting different diets after glycogen depletion.
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Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values.
TL;DR: Variation in muscle content of ATP, ATP + ADP + AMP, phosphorylcreatine (PC), creatine (Cr), PC + Cr, and glycogen, between legs, between sites on the same muscle, or as a result of error introduced during analysis, was small compared with the between-individuals variance.
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Intracellular free amino acid concentration in human muscle tissue.
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Selective glycogen depletion pattern in human muscle fibres after exercise of varying intensity and at varying pedalling rates
TL;DR: Glycogen depletion pattern in human skeletal muscle fibres was studied after bicycle exercise of varying intensity performed at different pedalling rates.
Journal ArticleDOI
Muscle Glycogen Synthesis after Exercise : an Enhancing Factor localized to the Muscle Cells in Man
Jonas Bergström,Eric Hultman +1 more
TL;DR: Goldstein1 has shown that a humoral factor, which decreases the blood glucose concentration, is released during exercise and it is known that the insulin requirement decreases in diabetic subjects during exercise.