Peroxygenases en route to becoming dream catalysts. What are the opportunities and challenges
TLDR
Peroxygenases are promising catalysts for preparative oxyfunctionalization chemistry as they combine the versatility of P450 monooxygenase with simplicity of cofactor-independent enzymes.About:
This article is published in Current Opinion in Chemical Biology.The article was published on 2017-04-01 and is currently open access. It has received 178 citations till now.read more
Citations
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Selective synthesis of 4-hydroxyisophorone and 4-ketoisophorone by fungal peroxygenases
Carmen Aranda,Martí Municoy,Victor Guallar,Jan Kiebist,Katrin Scheibner,René Ullrich,José C. del Río,Martin Hofrichter,Ángel T. Martínez,Ana Gutiérrez +9 more
TL;DR: Some fungal peroxygenases (UPOs) selectively oxidize α-isophorone to 4-hydroxyisophOrone and 4-ketoisophor one while others are less selective or unable.
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Accessing Chemo- and Regioselective Benzylic and Aromatic Oxidations by Protein Engineering of an Unspecific Peroxygenase
Anja Knorrscheidt,Jordi Soler,Nicole Hünecke,Pascal Püllmann,Marc Garcia-Borràs,Martin J. Weissenborn,Martin J. Weissenborn +6 more
TL;DR: The proposed evolutionary protocol and rationalization of the enhanced activities and selectivities acquired by MthUPO variants represent a step forward toward the use and implementation of UPOs in biocatalytic synthetic pathways of industrial interest.
Journal ArticleDOI
Surfing the wave of oxyfunctionalization chemistry by engineering fungal unspecific peroxygenases.
Alejandro Beltran-Nogal,Israel Sanchez-Moreno,Daniel Méndez-Sánchez,Patricia Gómez de Santos,Frank Hollmann,Miguel Alcalde +5 more
TL;DR: A review of the most recent advances in UPO engineering, both of the long and short UPO families, while discussing the future prospects in this fast-moving field of research can be found in this article .
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Novel Routes in Transformation of Lignocellulosic Biomass to Furan Platform Chemicals: From Pretreatment to Enzyme Catalysis
TL;DR: The present review provides an overview of the main processes that have been reported throughout the literature for the production of bio-based monomers from lignocellulose, focusing on physicochemical procedures and biocatalysis.
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A comprehensive insight into aldehyde deformylation: mechanistic implications from biology and chemistry
Umesh Kumar Bagha,Jagnyesh Kumar Satpathy,Gourab Mukherjee,Chivukula V. Sastri,Sam P. de Visser +4 more
TL;DR: This review paper provides an overview of the various aldehyde deformylation reactions in organic chemistry, biology and biomimetic model systems, and shows a broad range of different chemical reaction mechanisms for this process.
References
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Uwe T. Bornscheuer,Gjalt W. Huisman,Romas J. Kazlauskas,Romas J. Kazlauskas,Stefan Lutz,Jeffrey C. Moore,Karen Robins +6 more
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Vlada B. Urlacher,Marco Girhard +1 more
TL;DR: A short up-to-date overview of recent results on P450 engineering for technical applications including aspects of whole-cell biocatalysis with engineered recombinant enzymes and recently identified P450s with novel biotechnologically relevant properties are given.
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Guidelines and Cost Analysis for Catalyst Production in Biocatalytic Processes
TL;DR: It is seen that the fermentation yield in terms of final achievable cell concentration and expression level as well as the production scale are crucial for decreasing the total cost contribution of the biocatalyst.