Journal ArticleDOI
Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock?
Glenn Hernandez,Ricardo Castro,Carlos Romero,Claudio de la Hoz,Daniela Angulo,Ignacio Aranguiz,Jorge Larrondo,Andres Bujes,Alejandro Bruhn +8 more
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TLDR
The results support the need to review the current definition of septic shock and suggest hyperlactatemia could represent an objective parameter worth to be explored as a potential diagnostic criterion for septicshock.About:
This article is published in Journal of Critical Care.The article was published on 2011-08-01. It has received 83 citations till now. The article focuses on the topics: Hyperlactatemia & Septic shock.read more
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Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine
Maurizio Cecconi,Daniel De Backer,Massimo Antonelli,Richard Beale,Jan Bakker,Christoph Hofer,Roman Jaeschke,Alexandre Mebazaa,Michael R. Pinsky,Jean-Louis Teboul,Jean Louis Vincent,Andrew Rhodes +11 more
TL;DR: In this article, the authors provide support to the bedside clinician regarding the diagnosis, management and monitoring of circulatory shock, which is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate.
Journal ArticleDOI
Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial.
Glenn Hernandez,Gustavo A. Ospina-Tascón,Lucas P. Damiani,Elisa Estenssoro,Arnaldo Dubin,Javier Hurtado,Javier Hurtado,Gilberto Friedman,Ricardo Castro,Leyla Alegría,Jean-Louis Teboul,Maurizio Cecconi,Giorgio Ferri,Manuel Jibaja,Ronald Pairumani,Paula Virginia Fernández,Diego Barahona,Vladimir Granda-Luna,Alexandre Biasi Cavalcanti,Jan Bakker +19 more
TL;DR: Among patients with septic shock, a resuscitation strategy targeting normalization of capillary refill time, compared with a strategy targeting serum lactate levels, did not reduce all-cause 28-day mortality.
Journal ArticleDOI
Lactic Acidosis in Sepsis: It’s Not All Anaerobic: Implications for Diagnosis and Management
Bandarn Suetrong,Keith R. Walley +1 more
TL;DR: In this article, the authors discuss the clinical implications of serum lactate measurement in diagnosis, monitoring, and prognostication in acute and intensive care settings and explore treatment of lactic acidosis and its impact on clinical outcome.
Journal ArticleDOI
Early Goal-Directed Therapy in Severe Sepsis and Septic Shock: Insights and Comparisons to ProCESS, ProMISe, and ARISE
H. Bryant Nguyen,Anja Kathrin Jaehne,Namita Jayaprakash,Matthew W. Semler,Sara Hegab,Angel Coz Yataco,Geneva B. Tatem,Dhafer Salem,Steven Moore,Kamran Boka,Jasreen Gill,Jayna Gardner-Gray,Jacqueline Pflaum,Juan Pablo Domecq,Juan Pablo Domecq,Gina Hurst,Justin B. Belsky,Raymond Fowkes,Ronald Elkin,Steven Q. Simpson,Jay L. Falk,Daniel J. Singer,Emanuel P. Rivers +22 more
TL;DR: A review of the early hemodynamic pathogenesis, historical development, and definition of early goal-directed therapy, comparing trial conduction methodology and the changing landscape of sepsis mortality, are essential for an appropriate interpretation of these trials and their conclusions.
Journal ArticleDOI
Lactate as a Hemodynamic Marker in the Critically Ill
TL;DR: This review focuses on the use of lactate as a marker for risk stratification, lactate clearance as a hemodynamic endpoint, and its use compared to mixed venous oxygenation as a resuscitation goal.
References
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Journal ArticleDOI
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
Roger C. Bone,Robert A. Balk,F. B. Cerra,R. P. Dellinger,A. M. Fein,William A. Knaus,Roland M. H. Schein,W. J. Sibbald +7 more
TL;DR: An American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference was held in Northbrook in August 1991 with the goal of agreeing on a set of definitions that could be applied to patients with sepsis and its sequelae as mentioned in this paper.
Journal ArticleDOI
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
Emanuel P. Rivers,Bryant Nguyen,Suzanne Havstad,Julie Ressler,Alexandria Muzzin,Bernhard P. Knoblich,Edward L. Peterson,Michael C. Tomlanovich +7 more
TL;DR: This study randomly assigned patients who arrived at an urban emergency department with severe sepsis or septic shock to receive either six hours of early goal-directed therapy or standard therapy (as a control) before admission to the intensive care unit.
Journal ArticleDOI
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.
Derek C. Angus,Walter T. Linde-Zwirble,Jeffrey Lidicker,Gilles Clermont,Joseph A. Carcillo,Michael R. Pinsky +5 more
TL;DR: Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction, and is especially common in the elderly and is likely to increase substantially as the U.S. population ages.
Journal ArticleDOI
Efficacy and safety of recombinant human activated protein C for severe sepsis.
G Ordon R. B Ernard,J Ean L Ouis V Incent,L Aterre,S Teven P. L A R Osa,J Ean,A Ngel L Opez,J Ay S. S Teingrub,G Ary E. G Arber,J Effrey,D. H Elterbrand,E. W Esley E Ly,C Harles J. F Isher,S Evere S Epsis,S Tudy G Roup +13 more
TL;DR: This phase 3 trial assessed whether treatment with drotrecogin alfa activated reduced the rate of death from any cause among patients with severe sepsis.
Journal ArticleDOI
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
Mitchell M. Levy,Mitchell P. Fink,John C. Marshall,Edward Abraham,Derek C. Angus,Deborah J. Cook,Jonathan M. Cohen,Steven M. Opal,Jean Louis Vincent,Graham Ramsay +9 more
TL;DR: This document reflects a process whereby a group of experts and opinion leaders revisited the 1992 sepsis guidelines and found that apart from expanding the list of signs and symptoms of sepsi to reflect clinical bedside experience, no evidence exists to support a change to the definitions.
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Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.
R. P. Dellinger,Mitchell M. Levy,Andrew Rhodes,Djillali Annane,Herwig Gerlach,Steven M. Opal,Jonathan E. Sevransky,Charles L. Sprung,Ivor S. Douglas,Roman Jaeschke,Tiffany M. Osborn,Mark E. Nunnally,Konrad Reinhart,Ruth M. Kleinpell,Derek C. Angus,Clifford S. Deutschman,Flávia Ribeiro Machado,Gordon D. Rubenfeld,Steven A R Webb,Richard Beale,Jean Louis Vincent,Rui Moreno +21 more