Journal ArticleDOI
Phenyl Trimethylsilyl Sulfide-Mediated Controlled Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides
TLDR
P phenyl trimethylsilyl sulfide (PhS-TMS), an inexpensive and commercially available compound, mediates rapid ROP of a broad scope of NCA monomers, produces functional poly(amino acids) (PAAs) with controllable molecular weights, narrow polydispersity index (PDI), and an in situ generated phenyl thioester group at the C-terminus (PAA-SPhs).About:
This article is published in Biomacromolecules.The article was published on 2016-01-29. It has received 63 citations till now. The article focuses on the topics: Living polymerization & Ring-opening polymerization.read more
Citations
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Journal ArticleDOI
Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application
Ziyuan Song,Zhiyuan Han,Shixian Lv,Shixian Lv,Chongyi Chen,Chongyi Chen,Li Chen,Li Chen,Lichen Yin,Jianjun Cheng +9 more
TL;DR: This review article highlights the recent advances in the design of polypeptide-based supramolecular structures, including complexes with nucleic acids, micelles, vesicles, hybrid nanoparticles, and hydrogels, and discusses the future opportunities in this field.
Journal ArticleDOI
Recent Trends in Catalytic Polymerizations
TL;DR: In this article, the authors describe polymers as one of the largest and most important materials we use in daily life and their popularity has stemmed from their wide range of material properties combined with their low cost of manufacturing.
Journal ArticleDOI
Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids.
Alicia Rasines Mazo,Stephanie Allison-Logan,Fatemeh Karimi,Fatemeh Karimi,Nicholas Jun-An Chan,Wenlian Qiu,Wei Duan,Neil M O'Brien-Simpson,Greg G. Qiao +8 more
TL;DR: Key architectures obtained through NCA ROP or in combination with other polymerization methods are reviewed, as these play an important role in the wide range of applications towards which polypeptides have been applied.
Journal ArticleDOI
Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N -carboxyanhydrides
TL;DR: Lithium hexamethyldisilazide is used to initiate α-amino acid N-carboxyanhydride polymerizations that is very fast and can be conducted in an open vessel, and rapid synthesis of polypeptide libraries for high-throughput functional screening.
Journal ArticleDOI
Poly(α-l-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives.
Maochao Zheng,Miao Pan,Wancong Zhang,Huanchang Lin,Shenlang Wu,Chao Lu,Shijie Tang,Daojun Liu,Jianfeng Cai +8 more
TL;DR: This review aims to summarize the recent advances in PLL-based nanomaterials in these biomedical fields over the last decade by describing the synthesis of PLL and its derivatives and the main text of their recent biomedical applications and translational studies.
References
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PatentDOI
Synthesis of proteins by native chemical ligation
TL;DR: The technique of native chemical ligation is employable for chemically synthesizing full length proteins as discussed by the authors, which are chemically identical to proteins produced by cell free synthesis, and can be refolded and/or oxidized to form native disulfide-containing protein molecules.
Journal ArticleDOI
Stimuli-responsive polypeptide vesicles by conformation-specific assembly.
TL;DR: The preparation of diblock copolypeptides that self-assemble into spherical vesicular assemblies whose size and structure are dictated primarily by the ordered conformations of the polymer segments, in a manner similar to viral capsid assembly is reported.
Journal ArticleDOI
Chemoselective Ligation and Modification Strategies for Peptides and Proteins
TL;DR: This Review summarizes recent developments in the field of chemoselective ligation and modification strategies and illustrates their application, with examples ranging from the total synthesis of proteins to the semisynthesis of naturally modified proteins.
Journal ArticleDOI
Facile synthesis of block copolypeptides of defined architecture
TL;DR: A polymerization strategy that overcomes difficulties by using organonickel initiators which suppress chain-transfer and termination side reactions is described, which allows the facile synthesis of block copolypeptides with well-defined sequences, which might provide new peptide-based biomaterials with potential applications in tissue engineering, drug delivery and biomimetic composite formation.
Journal ArticleDOI
Synthesis of Well-Defined Polypeptide-Based Materials via the Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides
TL;DR: This review highlights the mechanistic developments of the ROP of NCAs from the conventional to the living initiating systems/methods; the second is dedicated to the synthesis of polypeptide hybrids with different macromolecular architectures; and the third deals with surface-boundpolypeptides.
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HEXAMETHYLDISILAZANE-MEDIATED CONTROLLED POLYMERIZATION OF α-AMINO ACID N- CARBOXYANHYDRIDES
Hua Lu,Jianjun Cheng +1 more