Journal ArticleDOI
Physico-chemical characterisation of PLGA nanoparticles after freeze-drying and storage
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TLDR
It was demonstrated that 1% sucrose or 2% trehalose were suitable to maintain particle integrity after reconstitution of lyophilised PLGA nanoparticles, and showed notable changes in mean particle size, size distribution, and residual moisture content, depending on the composition of the formulation.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2009-06-01. It has received 112 citations till now. The article focuses on the topics: PLGA & Particle size.read more
Citations
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Transport of drugs across the blood-brain barrier by nanoparticles.
TL;DR: The delivery of drugs, which usually are not able to cross the BBB, into the brain was confirmed by the biodistribution studies and pharmacological assays in rodents, and the presence of nanoparticles in the brain parenchyma was visualized by electron microscopy, suggesting that this technology holds great promise for non-invasive therapy of the CNS diseases.
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Lipid–polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review
TL;DR: The current state of development for the LPNs preparation and applications is detailed, from which future research works needed to bring theLPNs closer to its clinical realization are identified.
Journal ArticleDOI
Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives.
Anubhab Mukherjee,Ariana K Waters,Pranav Kalyan,Achal S. Achrol,Santosh Kesari,Venkata Mahidhar Yenugonda +5 more
TL;DR: A fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids.
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Antioxidant effects of quercetin and catechin encapsulated into PLGA nanoparticles
Hector Pool,David Quintanar,Juan de Dios Figueroa,Camila Marinho Mano,J. Etelvino H. Bechara,Luis A. Godínez,Sandra Mendoza +6 more
TL;DR: In this article, polymeric nanoparticles (PLGA) have been developed for the encapsulation and controlled release of quercetin and catechin using a solvent displacement method, and physicochemical properties measured by light scattering, scanning electron microscopy and ζ-potential, X-ray diffraction, infrared spectroscopy and differential scanning calorimetry.
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Facts and evidences on the lyophilization of polymeric nanoparticles for drug delivery.
TL;DR: This review updates the fundaments involved in the optimization procedures for lyophilization of polymeric nanoparticles, with the aim of obtaining the maximum stability of formulations.
References
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Journal ArticleDOI
Lyophilization and development of solid protein pharmaceuticals
TL;DR: Four interrelated topics are discussed: lyophilization and its denaturation stresses, cryo- and lyo-protection of proteins by excipients, design of a robust lyophILization cycle, and with emphasis, instability, stabilization, and formulation of solid protein pharmaceuticals.
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Rational design of stable lyophilized protein formulations: some practical advice.
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Optimization of the preparation process for human serum albumin (HSA) nanoparticles.
TL;DR: A pump-controlled preparation method was established which enabled particle preparation under defined conditions and the reproducibility of the particle size and particle size distribution under the proposed preparation conditions was demonstrated.
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Melting and glass transitions of low molecular weight carbohydrates
TL;DR: In this article, the glass transition temperatures at various water contents (Tg) and in maximally freeze-concentrated solutions (T′g), fusion temperatures (melting points, Tf), and heats of fusion (ΔHf) were determined for pentoses, hexoses, disaccharides, and alditols, using differential scanning calorimetry.
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