Journal ArticleDOI
Physiology of obesity and effects on lung function.
Cheryl M. Salome,Gregory G. King,Gregory G. King,Gregory G. King,Norbert Berend,Norbert Berend +5 more
TLDR
Obesity has effects on lung function that can reduce respiratory well-being, even in the absence of specific respiratory disease, and may also exaggerate the effects of existing airway disease.Abstract:
In obese people, the presence of adipose tissue around the rib cage and abdomen and in the visceral cavity loads the chest wall and reduces functional residual capacity (FRC). The reduction in FRC and in expiratory reserve volume is detectable, even at a modest increase in weight. However, obesity has little direct effect on airway caliber. Spirometric variables decrease in proportion to lung volumes, but are rarely below the normal range, even in the extremely obese, while reductions in expiratory flows and increases in airway resistance are largely normalized by adjusting for lung volumes. Nevertheless, the reduction in FRC has consequences for other aspects of lung function. A low FRC increases the risk of both expiratory flow limitation and airway closure. Marked reductions in expiratory reserve volume may lead to abnormalities in ventilation distribution, with closure of airways in the dependent zones of the lung and ventilation perfusion inequalities. Greater airway closure during tidal breathing is associated with lower arterial oxygen saturation in some subjects, even though lung CO-diffusing capacity is normal or increased in the obese. Bronchoconstriction has the potential to enhance the effects of obesity on airway closure and thus on ventilation distribution. Thus obesity has effects on lung function that can reduce respiratory well-being, even in the absence of specific respiratory disease, and may also exaggerate the effects of existing airway disease.read more
Citations
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DatasetDOI
Effect of Central Adiposity on Lung Function Tests in Young Adults
TL;DR: A significant decrease in expiratory reserve volume (ERV) and maximum voluntary ventilation (MVV) along with a significant correlation between WC and MVV and ERV in obese population of both sexes suggesting a lower pulmonary reserve which in the future may lead to respiratory diseases if weight reduction is not undertaken.
Journal ArticleDOI
Association of Pulmonary Function with Waist Circumference (WC) and Body Mass Index (BMI) among the Students of Management & Science University, Malaysia
TL;DR: Investigation of pulmonary function variables in the adolescent obese students of management and science university (MSU) in Malaysia found no significant difference in mean pulmonary function parameters between obese and nonobese control group, and significant negative correlation between BMI, waist circumference and hip circumference with FEV1/FVC suggest that obesity decreases FEV 1-FVC ratio and obese are more prone to obstructive lung diseases.
Journal ArticleDOI
Higher Work of Breathing during Exercise in Heart Failure with Preserved Ejection Fraction.
Nicolas Villarraga,Brit R. Warner,E Bruhn,Shane M. Hammer,Thomas G. Bissen,Tomas Olsson,Joshua R. Smith +6 more
TL;DR: In this paper , the authors found that patients with heart failure with preserved ejection fraction (HFpEF) experienced higher work-of-breathing (Wb) and power of breathing (Pb) during exercise.
Journal ArticleDOI
Lungenfunktion bei älteren Probanden mit metabolischem Syndrom und Typ-2-Diabetes: Ergebnisse der Berliner Altersstudie II
Journal ArticleDOI
Effect of Body Composition on Ventilation Parameters in a Group of Young Sudanese Females
N. A. Alaagib,M.Y. Sukkar +1 more
TL;DR: Increase in BMI, body weight, WC and body fat showed positive significant correlation with FEV 1 % and may give a restrictive pattern in LFT and underweight subjects may show significant reduction in lung function if their BMI is not considered.
References
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Journal ArticleDOI
The Effects of Body Mass Index on Lung Volumes
TL;DR: It was showed that BMI has significant effects on all of the lung volumes, and the greatest effects were on FRC and ERV, which occurred at BMI values < 30 kg/m2, which will assist clinicians when interpreting PFT results in patients with normal airway function.
Journal ArticleDOI
Effects of obesity on respiratory function
TL;DR: It is concluded that obesity does not usually preclude use of usual predictors, and an abnormal pulmonary function test value should be considered as caused by intrinsic lung disease and not by obesity, except in those with extreme obesity.
Journal ArticleDOI
Compliance of the respiratory system and its components in health and obesity.
A. Naimark,Reuben M. Cherniack +1 more
TL;DR: The compliance of the total respiratory system and its components was studied in normal and obese spontaneously breathing unanesthetized subjects and found that the former are more compliant than the latter.
Journal ArticleDOI
The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia
Paolo Pelosi,M. Croci,I Ravagnan,Stefano Tredici,Alessia Pedoto,Alfredo Lissoni,Luciano Gattinoni +6 more
TL;DR: The effects of body mass index (BMI) on functional residual capacity (FRC), respiratory mechanics, respiratory mechanics (compliance and resistance), gas exchange, and the inspiratory mechanical work done per liter of ventilation during general anesthesia are investigated.
Journal ArticleDOI
Effects of Obesity on Respiratory Resistance
TL;DR: It is suggested that in addition to the elastic load, obese subjects have to overcome increased respiratory resistance resulting from the reduction in lung volumes related to being overweight.
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