Journal ArticleDOI
Physiology of obesity and effects on lung function.
Cheryl M. Salome,Gregory G. King,Gregory G. King,Gregory G. King,Norbert Berend,Norbert Berend +5 more
TLDR
Obesity has effects on lung function that can reduce respiratory well-being, even in the absence of specific respiratory disease, and may also exaggerate the effects of existing airway disease.Abstract:
In obese people, the presence of adipose tissue around the rib cage and abdomen and in the visceral cavity loads the chest wall and reduces functional residual capacity (FRC). The reduction in FRC and in expiratory reserve volume is detectable, even at a modest increase in weight. However, obesity has little direct effect on airway caliber. Spirometric variables decrease in proportion to lung volumes, but are rarely below the normal range, even in the extremely obese, while reductions in expiratory flows and increases in airway resistance are largely normalized by adjusting for lung volumes. Nevertheless, the reduction in FRC has consequences for other aspects of lung function. A low FRC increases the risk of both expiratory flow limitation and airway closure. Marked reductions in expiratory reserve volume may lead to abnormalities in ventilation distribution, with closure of airways in the dependent zones of the lung and ventilation perfusion inequalities. Greater airway closure during tidal breathing is associated with lower arterial oxygen saturation in some subjects, even though lung CO-diffusing capacity is normal or increased in the obese. Bronchoconstriction has the potential to enhance the effects of obesity on airway closure and thus on ventilation distribution. Thus obesity has effects on lung function that can reduce respiratory well-being, even in the absence of specific respiratory disease, and may also exaggerate the effects of existing airway disease.read more
Citations
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Journal ArticleDOI
Hubungan obesitas dengan faal paru pada mahasiswa fakultas kedokteran universitas sam ratulangi manado
TL;DR: The correlation between Body Mass Index (BMI) and FVC and FEV1 is found to be insignificant and increase in BMI can lower the lungs function.
Journal ArticleDOI
The effect of body mass index on the development of acute kidney injury and mortality in intensive care unit: is obesity paradox valid?
Mehmet Süleyman Sabaz,Sinan Aşar,Gökhan Sertçakacılar,Nagihan Sabaz,Zafer Çukurova,Gülsüm Oya Hergünsel +5 more
TL;DR: In this paper, conflicting results of studies on intensive care unit (ICU) mortality of obese patients and obese patients with acute kidney injury (AKI) reveal a paradox within a paradox.
Journal ArticleDOI
Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study
Andre F.S. Amaral,Medea Imboden,Medea Imboden,Matthias Wielscher,Faisal I. Rezwan,Cosetta Minelli,Judith Garcia-Aymerich,Gabriela P. Peralta,Juha Auvinen,Ayoung Jeong,Ayoung Jeong,Emmanuel Schaffner,Emmanuel Schaffner,Anna Beckmeyer-Borowko,Anna Beckmeyer-Borowko,John W. Holloway,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Nicole Probst-Hensch,Nicole Probst-Hensch,Deborah Jarvis +20 more
TL;DR: This is the first paper to report the use of a two-step MR approach to assess the role of DNA methylation in mediating the effect of a non-genetic factor on lung function and the findings do not support a mediating effect.
Journal ArticleDOI
Lung function and left ventricular hypertrophy in morbidly obese candidates for bariatric surgery
Paulo de Tarso Müller,Hamilton Domingos,Luiz Armando Pereira Patusco,Gabriel Victor Guimarães Rapello +3 more
TL;DR: A reduction in the relative size of the small airways appears to be independently correlated with obesity-related cardiac hypertrophy, regardless of factors affecting respiratory mechanics, gender, or history of systemic arterial hypertension, and FEV1 and FVC might be important predictors of left ventricular mass in morbidly obese individuals.
Effect of central obesity on some pulmonary function tests in women
TL;DR: Looking at the results of spirometry in obese women, it is clear that the lung function parameters (FVC and FEV1) deteriorated markedly with increasing each of (WC and WHR), and the results showed that COG (according to WC or WHR) had significantly lower FVC andFEV1 than POG, with significant negative correlations between each index of central Obesity.
References
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Journal ArticleDOI
The Effects of Body Mass Index on Lung Volumes
TL;DR: It was showed that BMI has significant effects on all of the lung volumes, and the greatest effects were on FRC and ERV, which occurred at BMI values < 30 kg/m2, which will assist clinicians when interpreting PFT results in patients with normal airway function.
Journal ArticleDOI
Effects of obesity on respiratory function
TL;DR: It is concluded that obesity does not usually preclude use of usual predictors, and an abnormal pulmonary function test value should be considered as caused by intrinsic lung disease and not by obesity, except in those with extreme obesity.
Journal ArticleDOI
Compliance of the respiratory system and its components in health and obesity.
A. Naimark,Reuben M. Cherniack +1 more
TL;DR: The compliance of the total respiratory system and its components was studied in normal and obese spontaneously breathing unanesthetized subjects and found that the former are more compliant than the latter.
Journal ArticleDOI
The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia
Paolo Pelosi,M. Croci,I Ravagnan,Stefano Tredici,Alessia Pedoto,Alfredo Lissoni,Luciano Gattinoni +6 more
TL;DR: The effects of body mass index (BMI) on functional residual capacity (FRC), respiratory mechanics, respiratory mechanics (compliance and resistance), gas exchange, and the inspiratory mechanical work done per liter of ventilation during general anesthesia are investigated.
Journal ArticleDOI
Effects of Obesity on Respiratory Resistance
TL;DR: It is suggested that in addition to the elastic load, obese subjects have to overcome increased respiratory resistance resulting from the reduction in lung volumes related to being overweight.
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