Journal ArticleDOI
Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation
Attilio Marino,Attilio Marino,Satoshi Arai,Yanyan Hou,Edoardo Sinibaldi,Mario Pellegrino,Young-Tae Chang,Young-Tae Chang,Barbara Mazzolai,Virgilio Mattoli,Madoka Suzuki,Gianni Ciofani +11 more
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TLDR
Following application of ultrasounds to cells treated with BTNPs, fluorescence imaging of ion dynamics revealed that the synergic stimulation is able to elicit a significant cellular response in terms of calcium and sodium fluxes; moreover, tests with appropriate blockers demonstrated that voltage-gated membrane channels are activated.Abstract:
Tetragonal barium titanate nanoparticles (BTNPs) have been exploited as nanotransducers owing to their piezoelectric properties, in order to provide indirect electrical stimulation to SH-SY5Y neuron-like cells. Following application of ultrasounds to cells treated with BTNPs, fluorescence imaging of ion dynamics revealed that the synergic stimulation is able to elicit a significant cellular response in terms of calcium and sodium fluxes; moreover, tests with appropriate blockers demonstrated that voltage-gated membrane channels are activated. The hypothesis of piezoelectric stimulation of neuron-like cells was supported by lack of cellular response in the presence of cubic nonpiezoelectric BTNPs, and further corroborated by a simple electroelastic model of a BTNP subjected to ultrasounds, according to which the generated voltage is compatible with the values required for the activation of voltage-sensitive channels.read more
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Neural recording and modulation technologies
TL;DR: The design lessons from the quarter-century-old field of neural engineering are discussed, recent materials-driven progress in neural probes are highlighted, and emergent directions inspired by the principles of neural transduction are looked at.
Journal ArticleDOI
Next-generation probes, particles, and proteins for neural interfacing
Jonathan Rivnay,Jonathan Rivnay,Huiliang Wang,Lief E. Fenno,Karl Deisseroth,George G. Malliaras +5 more
TL;DR: This Review describes how the understanding of neural signaling and material-tissue interactions has fueled the expansion of the available tool set and will support new neurotherapies and prostheses and provide neuroscientists and neurologists with unprecedented access to the brain.
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Ultrasound Neuromodulation: A Review of Results, Mechanisms and Safety.
TL;DR: The literature supports the use of US as a safe, non-invasive brain stimulation modality with improved spatial localization and depth targeting compared with alternative methods.
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Piezoelectric Nano‐Biomaterials for Biomedicine and Tissue Regeneration
TL;DR: The major focus is to highlight the wide range of applications of piezoelectric nano‐biomaterials in drug delivery, theranostics, and tissue regeneration, with specific focus on barium titanate, zinc oxide, and polyvinylidene fluoride.
Journal ArticleDOI
Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair
TL;DR: This article summarizes the significant progress in the field with a focus on the fabrication aspects of piezoelectric materials and shows great potential for fabricating smart stimulatory scaffolds for bone tissue engineering.
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Optical Deconstruction of Parkinsonian Neural Circuitry
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Microfibre–nanowire hybrid structure for energy scavenging
TL;DR: This work establishes a methodology for scavenging light-wind energy and body-movement energy using fabrics and presents a simple, low-cost approach that converts low-frequency vibration/friction energy into electricity using piezoelectric zinc oxide nanowires grown radially around textile fibres.