Journal ArticleDOI
Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus.
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TLDR
It was concluded that the rapid and large daily changes in N-acetyltransferase activity seen in a normal lighting cycle and the much slower and smaller changes in hydroxyindole-O-methyltransferaseActivity seen only after weeks in constant lighting conditions are mediated by the same neural tract.About:
This article is published in Brain Research.The article was published on 1979-10-05. It has received 572 citations till now. The article focuses on the topics: Retinohypothalamic tract & Neural tract.read more
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An action spectrum for melatonin suppression: evidence for a novel non‐rod, non‐cone photoreceptor system in humans
TL;DR: The data strongly support a primary role for a novel short‐wavelength photopigment in light‐induced melatonin suppression and provide the first direct evidence of a non‐rod, non‐cone photoreceptive system in humans.
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The basic physiology and pathophysiology of melatonin
TL;DR: Although functions of this hormone in humans are mainly based on correlative observations, there is some evidence that melatonin stabilises and strengthens coupling of circadian rhythms, especially of core temperature and sleep-wake rhythms.
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Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters
TL;DR: The aim of this review is to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis, which reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism.
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Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways.
Seithikurippu R. Pandi-Perumal,Ilya Trakht,Venkataramanujan Srinivasan,D. Warren Spence,Georges J.M. Maestroni,Nava Zisapel,Daniel P. Cardinali +6 more
TL;DR: The evidence concerning melatonin receptors and signal transduction pathways in various organs is reviewed and their relevance to circadian physiology and pathogenesis of certain human diseases, with a focus on the brain, the cardiovascular and immune systems, and cancer is considered.
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Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors.
TL;DR: Despite the loss of all known retinal photoreceptors, rd/rd cl mice showed normal suppression of pineal melatonin in response to monochromatic light of wavelength 509 nanometers, indicating that mammals have additional ocular photoreceptorors that they use in the regulation of temporal physiology.
References
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Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat.
TL;DR: The purpose of the present study was to reinvestigate the role of the central retinal projections in neuroendocrine regulation and find that lesions in the suprachiasmatic region of the hypothalamus abolish the constant estrous response to light in the female rat.
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Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions
TL;DR: Bilateral electrolytic lesions in the suprachiasmatic nuclei permanently eliminated nocturnal and circadian rhythms in drinking behavior and locomotor activity of albino rats.
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A retinohypothalamic projection in the rat
Robert Y. Moore,Nicholas J. Lenn +1 more
TL;DR: The retinohypothalamic tract in the rat appears to arise from the ganglion cells of the retina and to terminate on the smaller dendritic branches of the neurons of the suprachiasmatic nucleus.
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Direct hypothalamo-autonomic connections.
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Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N-Acetyltransferase
David C. Klein,Joan L. Weller +1 more
TL;DR: Experiments in vitro indicate that norepinephrine, not serotonin, regulates the activity of N-acetyl-transferase through a highly specific receptor.