Predicting COVID-19—Comorbidity Pathway Crosstalk-Based Targets and Drugs: Towards Personalized COVID-19 Management
Debmalya Barh,Alaa A. A. Aljabali,Murtaza M. Tambuwala,Sandeep Tiwari,Ángel Serrano-Aroca,Khalid J. Alzahrani,Bruno Silva Andrade,Vasco Azevedo,Nirmal Kumar Ganguly,Nirmal Kumar Ganguly,Kenneth Lundstrom +10 more
TLDR
In this paper, the pathway crosstalk between COVID-19 and diabetes, hypertension, CVDs, chronic kidney diseases (CKDs), cancers, and chronic obstructive pulmonary disease (COPD) was identified.Abstract:
It is well established that pre-existing comorbid conditions such as hypertension, diabetes, obesity, cardiovascular diseases (CVDs), chronic kidney diseases (CKDs), cancers, and chronic obstructive pulmonary disease (COPD) are associated with increased severity and fatality of COVID-19. The increased death from COVID-19 is due to the unavailability of a gold standard therapeutic and, more importantly, the lack of understanding of how the comorbid conditions and COVID-19 interact at the molecular level, so that personalized management strategies can be adopted. Here, using multi-omics data sets and bioinformatics strategy, we identified the pathway crosstalk between COVID-19 and diabetes, hypertension, CVDs, CKDs, and cancers. Further, shared pathways and hub gene-based targets for COVID-19 and its associated specific and combination of comorbid conditions are also predicted towards developing personalized management strategies. The approved drugs for most of these identified targets are also provided towards drug repurposing. Literature supports the involvement of our identified shared pathways in pathogenesis of COVID-19 and development of the specific comorbid condition of interest. Similarly, shared pathways- and hub gene-based targets are also found to have potential implementations in managing COVID-19 patients. However, the identified targets and drugs need further careful evaluation for their repurposing towards personalized treatment of COVID-19 cases having pre-existing specific comorbid conditions we have considered in this analysis. The method applied here may also be helpful in identifying common pathway components and targets in other disease-disease interactions too.read more
Citations
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Antiviral Face Mask Functionalized with Solidified Hand Soap: Low-Cost Infection Prevention Clothing against Enveloped Viruses Such as SARS-CoV-2.
Alba Cano-Vicent,Alberto Tuñón-Molina,Miguel Martí,Yukiko Muramoto,Takeshi Noda,Kazuo Takayama,Ángel Serrano-Aroca +6 more
TL;DR: In this paper, an easy fabrication method of a novel antiviral non-woven fabric containing polymer filaments that were coated with solidified hand soap was reported. This extra protective fabric is capable of inactivating enveloped viruses such as SARS-CoV-2 and phage Φ6 within 1 min of contact.
Posted ContentDOI
SARS-CoV-2 variants show a gradual declining pathogenicity and pro-inflammatory cytokine spur, an increasing antigenic and antiinflammatory cytokine induction, and rising structural protein instability
Debmalya Barh,Sandeep Tiwari,L. G. R. Gomes,Cecília H.R. Pinto,B. Andrade,Shaban Ahmad,Alaa A. A. Aljabali,Khalid J. Alzahrani,H. Banjer,Sk. Sarif Hassan,Murtaza M. Tambuwala,Elrashdy M. Redwan,Khalid Raza,Vasco Azevedo,Kenneth Lundstrom,Vladimir N. Uversky +15 more
TL;DR: Analysis of randomly selected genome sequences of SARS-CoV-2 variants submitted to NCBI from 15 to 31 December 2021 reveals hyper-transmissibility with decreased disease severity and the highest instability of Omicron E protein may also be associated with decreased viral maturation and low viral load leading to less severe disease and faster recovery.
Journal ArticleDOI
COVID-19 signalome: Pathways for SARS-CoV-2 infection and impact on COVID-19 associated comorbidity
Kenneth Lundstrom,Altijana Hromic-Jahjefendic,Esma Bilajac,Alaa A. A. Aljabali,Katarina Baralić,Nagwa Ali Sabri,Eslam Mansour Shehata,Mohamed A. Raslan,A. Ferreira,Lidiane Orlandi,Ángel Serrano-Aroca,Murtaza M. Tambuwala,Vladimir N. Uversky,Vasco Azevedo,K. Alzahrani,Khalaf F. Alsharif,Ibrahim Faisal Halawani,Fuad M. Alzahrani,Elrashdy M. Redwan,Debmalya Barh +19 more
TL;DR: The major breakthrough was made by discovering pathways related to SARS-CoV-2 infection through cellular interaction by angiotensin-converting enzyme (ACE2) and cytokine storm as discussed by the authors .
Journal ArticleDOI
Immune Response Is Key to Genetic Mechanisms of SARS-CoV-2 Infection With Psychiatric Disorders Based on Differential Gene Expression Pattern Analysis
Jing Xia,Shuhan Chen,Yaping Li,Hua Li,Ming Ying Gan,Jiashuo Wu,Clare Prohaska,Yang Bai,L. Gao,Lili Gu,Dong-Fang Zhang +10 more
TL;DR: By elucidating the relationship between the pathogenetic processes and genetic mechanisms of infection with SARS-CoV-2 with psychiatric disorders, it is hoped that it will lead to innovative strategies for future research and treatment of psychiatric disorders linked to COVID-19.
Journal ArticleDOI
Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method
Golnaz Taheri,Mahnaz Habibi +1 more
TL;DR: Habibi et al. as mentioned in this paper proposed a two-stage machine learning approach for pathway analysis, during the first stage, four informative gene sets that can represent important COVID-19 related pathways are selected.
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