Journal ArticleDOI
Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery.
Yu Hsin Lin,Fwu Long Mi,Chiung-Tong Chen,Wei Chun Chang,Shu Fen Peng,Hsiang Fa Liang,Hsing-Wen Sung +6 more
TLDR
The in vivo results clearly indicated that the insulin-loaded NPs could effectively reduce the blood glucose level in a diabetic rat model because of their stability in distinct pH environments.About:
This article is published in Biomacromolecules.The article was published on 2007-01-01. It has received 346 citations till now.read more
Citations
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Chitosan-based nanomaterials: A state-of-the-art review
TL;DR: Chitosan based nanomaterials have superior physical and chemical properties such as high surface area, porosity, tensile strength, conductivity, photo-luminescent as well as increased mechanical properties as comparison to pure chitOSan.
Journal ArticleDOI
Alginate/chitosan nanoparticles are effective for oral insulin delivery.
Bruno Sarmento,António J. Ribeiro,Francisco Veiga,Paula Sampaio,Ronald J. Neufeld,Domingos Ferreira +5 more
TL;DR: The results indicate that the encapsulation of insulin into mucoadhesive nanoparticles was a key factor in the improvement of its oral absorption and oral bioactivity.
Journal ArticleDOI
Chitosan Nanoparticles: A Promising System in Novel Drug Delivery
TL;DR: The present review describes origin and properties of chitosan and its nanoparticles along with the different methods of its preparation and the various areas of novel drug delivery where it has got its application.
Journal ArticleDOI
A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery.
TL;DR: The gastrointestinal barriers to oral insulin delivery, including chemical, enzymatic and absorption barriers, are described and the potential transport mechanisms of insulin delivered by nanoparticles across the intestinal epithelium are discussed.
Journal ArticleDOI
Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules.
Mei Chin Chen,Fwu Long Mi,Zi-Xian Liao,Chun-Wen Hsiao,Kiran Sonaje,Min Fan Chung,Li Wen Hsu,Hsing-Wen Sung +7 more
TL;DR: The synthesis of CS derivatives and their characteristics, as well as their potential transport mechanisms of macromolecular therapeutics across the intestinal biological membrane, are described.
References
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Journal ArticleDOI
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
TL;DR: It is concluded that Caco-2 cells grown on collagen-coated polycarbonate membranes should represent a valuable transport model system for the small intestinal epithelium.
Journal ArticleDOI
Measurement of gastrointestinal pH profiles in normal ambulant human subjects.
TL;DR: Gastrointestinal pH has been measured in 66 normal subjects using a pH sensitive radiotelemetry capsule passing freely through the gastrointestinal tract, enabling unconstrained measurements with normal ambulatory activities for up to 48 h during normal GI transit.
Journal ArticleDOI
Microencapsulated chitosan nanoparticles for lung protein delivery
TL;DR: This work demonstrated that protein-loaded nanoparticles could be successfully incorporated into microspheres with adequate characteristics to reach the deep lung, which after contact with its aqueous environment are expected to be able to release the nanoparticles, and thus, the therapeutic macromolecule.
Journal ArticleDOI
The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro
Gerrit Borchard,Henrik L. Lueβen,Albertus G. de Boer,J. Coos Verhoef,C.-M. Lehr,Hans E. Junginger +5 more
TL;DR: A threshold value of about 50% of TEER reduction has been identified, which allows for transport of hydrophilic compounds across the cell monolayers of the Caco-2 cell model.
Journal ArticleDOI
Chitosan and its derivatives as intestinal absorption enhancers.
TL;DR: Co-administrations of TMC with peptide drugs were found to substantially increase the bioavailability of the peptide in both rats and juvenile pigs compared with administrations without the polymer.