Progress in corneal wound healing
TLDR
Attention is paid to problems in wound healing understanding and treatment, such as lack of specific epithelial stem cell markers, reliable identification of stem cells, efficient prevention of haze and stromal scar formation, lack of data on wound regulating microRNAs in keratocytes and endothelial cells, as well as virtual lack of targeted systems for drug and gene delivery to select corneal cells.About:
This article is published in Progress in Retinal and Eye Research.The article was published on 2015-11-01 and is currently open access. It has received 526 citations till now. The article focuses on the topics: Stem-cell therapy & Wound healing.read more
Citations
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TFOS DEWS II pathophysiology report
Anthony J. Bron,Anthony J. Bron,Cintia S. de Paiva,Sunil K. Chauhan,Stefano Bonini,Eric E. Gabison,Sandeep Jain,Erich Knop,Maria Markoulli,Yoko Ogawa,Victor L. Perez,Yuichi Uchino,Norihiko Yokoi,Driss Zoukhri,David A. Sullivan +14 more
TL;DR: The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms involved in the initiation and perpetuation of dry eye disease, finding the targeting of the terminal duct in meibomian gland disease and the influence of gaze dynamics and the closed eye state on tear stability and ocular surface inflammation to be important.
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Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis
Daisy Y. Shu,Frank J. Lovicu +1 more
TL;DR: The pathological functions of the myofibroblast in fibrotic eye disease are introduced and recent developments in elucidating the multiple signaling pathways involved in fibrogenesis are highlighted that may be exploited in the development of novel anti‐fibrotic therapies to reduce ocular morbidity due to scarring.
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Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels
Ehsan Shirzaei Sani,Ahmad Kheirkhah,Devyesh Rana,Zhongmou Sun,William Foulsham,Amir Sheikhi,Amir Sheikhi,Ali Khademhosseini,Reza Dana,Nasim Annabi,Nasim Annabi +10 more
TL;DR: In vivo experiments showed that bioadhesive could effectively seal corneal defects and induce stromal regeneration and re-epithelialization, and GelCORE has many advantages including low cost and ease of production and use.
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Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z.
Salvatore Sciacchitano,Salvatore Sciacchitano,Luca Lavra,Alessandra Morgante,Alessandra Ulivieri,Fiorenza Magi,Gian Paolo De Francesco,Carlo Bellotti,Leila B. Salehi,Leila B. Salehi,Alberto Ricci +10 more
TL;DR: The current review aims to extensively examine the studies published so far on the role of Gal-3 in all the clinical conditions and diseases, listed in alphabetical order, where it was analyzed.
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Diabetic complications in the cornea.
TL;DR: Mechanisms of diabetic corneal abnormalities, available animal, tissue and organ culture models, and emerging treatments, as well as emerging gene and cell therapies are discussed in detail.
References
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Journal ArticleDOI
Silencing of microRNAs in vivo with ‘antagomirs’
Jan Krützfeldt,Nikolaus Rajewsky,Ravi Braich,Kallanthottathil G. Rajeev,Thomas Tuschl,Muthiah Manoharan,Markus Stoffel +6 more
TL;DR: It is shown that a novel class of chemically engineered oligonucleotides, termed ‘antagomirs’, are efficient and specific silencers of endogenous miRNA levels in mice and may represent a therapeutic strategy for silencing miRNAs in disease.
Journal ArticleDOI
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
Donald P. Bottaro,Jeffrey S. Rubin,D. L. Faletto,Andrew K Chan,Thomas E. Kmiecik,G F Vande Woude,Stuart A. Aaronson +6 more
TL;DR: A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the beta subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase.
Journal ArticleDOI
TGF-beta signaling and the fibrotic response.
Andrew Leask,David Abraham +1 more
TL;DR: The current state of knowledge concerning interactions among the profibrotic proteins transforming growth factor‐β (TGF‐β), connective tissue growth factor (CTGF, CCN2), and ED‐A fibronectin (ED‐A FN) and the antifib rotic proteins tumor necrosis factor‐α (TNF‐α) and γ‐interferon (IFN‐γ) is discussed.
Journal ArticleDOI
Treatment of HCV Infection by Targeting MicroRNA
Harry L.A. Janssen,Hendrik W. Reesink,Eric Lawitz,Stefan Zeuzem,Maribel Rodriguez-Torres,Keyur Patel,Adriaan J. van der Meer,Amy K. Patick,Alice Chen,Yi Zhou,Robert Persson,Barney D King,Sakari Kauppinen,Arthur A. Levin,Michael R. Hodges +14 more
TL;DR: The use of miravirsen in patients with chronic HCV genotype 1 infection showed prolonged dose-dependent reductions in HCV RNA levels without evidence of viral resistance.
Journal ArticleDOI
LNA-mediated microRNA silencing in non-human primates
Joacim Elmén,Morten Lindow,Sylvia Schütz,Matthew Lawrence,Andreas Petri,Susanna Obad,Marie Lindholm,Maj Hedtjärn,Henrik Frydenlund Hansen,Urs V. Berger,Steven R. Gullans,Phil Kearney,Peter Sarnow,Ellen Marie Straarup,Sakari Kauppinen,Sakari Kauppinen +15 more
TL;DR: The utility of systemically administered LNA-antimiRs in exploring miRNA function in rodents and primates is demonstrated, and the potential of these compounds as a new class of therapeutics for disease-associated miRNAs is supported.