Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases.
Warren Strober,Ivan J. Fuss +1 more
TLDR
This review will explore the cytokine landscape with the view of providing an understanding of how recent and future anticytokine therapies actually function.About:
This article is published in Gastroenterology.The article was published on 2011-05-01 and is currently open access. It has received 946 citations till now. The article focuses on the topics: Proinflammatory cytokine & Cytokine.read more
Citations
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Journal ArticleDOI
Cytokines in inflammatory bowel disease
TL;DR: The role of cytokines produced by innate and adaptive immune cells, as well as their relevance to the future therapy of IBD are discussed.
Journal ArticleDOI
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
Jochem H. Bernink,Charlotte P. Peters,Marius Munneke,Anje A. te Velde,Sybren L. Meijer,Kees Weijer,Hulda S. Hreggvidsdottir,Sigrid E.M. Heinsbroek,Nicolas Legrand,Nicolas Legrand,Christianne J. Buskens,Willem A. Bemelman,Jenny Mjösberg,Jenny Mjösberg,Hergen Spits +14 more
TL;DR: The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing I LC1 cells in the pathogenesis of gut mucosal inflammation.
Journal ArticleDOI
Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells
Anja Fuchs,William Vermi,William Vermi,Jacob S. Lee,Silvia Lonardi,Susan Gilfillan,Rodney D. Newberry,Marina Cella,Marco Colonna +8 more
TL;DR: A human ILC1 subset that produced interferon-γ (IFN-γ) in response to IL-12 and IL-15 and had a unique integrin profile, intraepithelial location, hallmarks of TGF-β imprinting, and a memory-activated phenotype is characterized.
Journal ArticleDOI
Experimental Models of Inflammatory Bowel Diseases
TL;DR: This brief review of murine models of intestinal inflammation focuses mainly on the most often used models that are, not incidentally, also the models that have yielded major insights into IBD pathogenesis.
Journal ArticleDOI
The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs, and Skin
TL;DR: This review focuses on recent advances in the biology of the Th17 pathway and on genome-wide association studies that implicate this immune pathway in human disease involving these tissues.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
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Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
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TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-Producing T cells
Marc Veldhoen,Richard J. Hocking,Christopher J. Atkins,Richard M. Locksley,Brigitta Stockinger +4 more
TL;DR: The data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation ofIL-17-producing T cells.
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Transforming growth factor-beta induces development of the T(H)17 lineage.
Paul R. Mangan,Laurie E. Harrington,Darrell B. O'Quinn,Whitney S. Helms,Daniel C. Bullard,Charles O. Elson,Robin D. Hatton,Sharon M. Wahl,Trenton R. Schoeb,Casey T. Weaver +9 more
TL;DR: This article identified transforming growth factor-beta (TGF-beta) as a cytokine critical for commitment to Thelper-17 (T(H)17) development, which is required for host protection against a bacterial pathogen, Citrobacter rodentium.
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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Richard H. Duerr,Kent D. Taylor,Steven R. Brant,Steven R. Brant,John D. Rioux,John D. Rioux,Mark S. Silverberg,Mark J. Daly,Mark J. Daly,A. Hillary Steinhart,Clara Abraham,Miguel Regueiro,Anne M. Griffiths,Themistocles Dassopoulos,Alain Bitton,Huiying Yang,Stephan R. Targan,Lisa W. Datta,Emily O. Kistner,L. Philip Schumm,Annette Lee,Peter K. Gregersen,M. Michael Barmada,Jerome I. Rotter,Dan L. Nicolae,Judy H. Cho +25 more
TL;DR: A highly significant association is found between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23, which prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease.