Journal ArticleDOI
Protein Immobilization Strategies for Protein Biochips
TLDR
Current protein immobilization strategies, including physical, covalent, and bioaffinity immobilization for the fabrication of protein biochips, are described and particular consideration has been given to oriented immobilization, also referred to as site-specific immobilized, which is believed will improve homogeneous surface covering and accessibility of the active site.About:
This article is published in Biomacromolecules.The article was published on 2007-04-20. It has received 861 citations till now.read more
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Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
TL;DR: This work presents a meta-analysis of the literature on food quality and safety analysis and its applications in the context of veterinary drugs and drugs and drug-Induced Antibodies, which focuses on the role of canine coronavirus in the veterinary industry.
Journal ArticleDOI
Point of care diagnostics: Status and future
TL;DR: This chapter discusses the development of personalized medicine and home testing in the developing world, and some of the strategies used to achieve this goal have not yet been developed.
Journal ArticleDOI
Chemical Strategies for Generating Protein Biochips
TL;DR: Different approaches using covalent and noncovalent chemistry are reviewed; particular emphasis is placed on the chemical specificity of protein attachment and on retention of protein function.
Journal ArticleDOI
Control of protein immobilization: coupling immobilization and site-directed mutagenesis to improve biocatalyst or biosensor performance.
TL;DR: The advances in support design and the deeper knowledge of the mechanisms of enzyme-support interactions have permitted exploration of the possibilities of the coupled use of site-directed mutagenesis and immobilization in a new way.
Journal ArticleDOI
Integrated optical devices for lab-on-a-chip biosensing applications
TL;DR: This review provides an extended overview of the state-of-the-art in integrated photonic biosensors technology including interferometers, grating couplers, microring resonators, photonic crystals and other novel nanophotonic transducers.
References
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Journal ArticleDOI
Formation and Structure of Self-Assembled Monolayers.
TL;DR: Monolayers of alkanethiolates on gold are probably the most studied SAMs to date and offer the needed design flexibility, both at the individual molecular and at the material levels, and offer a vehicle for investigation of specific interactions at interfaces, and of the effect of increasing molecular complexity on the structure and stability of two-dimensional assemblies.
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An fMRI Investigation of Emotional Engagement in Moral Judgment
Joshua D. Greene,R. Brian Sommerville,Leigh E. Nystrom,John M. Darley,Jonathan D. Cohen,Jonathan D. Cohen +5 more
TL;DR: It is argued that moral dilemmas vary systematically in the extent to which they engage emotional processing and that these variations in emotional engagement influence moral judgment.
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Printing proteins as microarrays for high-throughput function determination.
TL;DR: Miniaturized assays that accommodate extremely low sample volumes and enable the rapid, simultaneous processing of thousands of proteins are developed to facilitate subsequent studies of protein function.
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Adsorption of proteins onto surfaces containing end-attached oligo(ethylene oxide): a model system using self-assembled monolayers
TL;DR: In this paper, the adsorption of four proteins-fibrinogen, lysozyme, pyruvate kinase, and RNAse A-to self-assembled monolayers (SAMs) on gold was studied.
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Characterization of DNA Probes Immobilized on Gold Surfaces
Tonya M. Herne,Michael J. Tarlov +1 more
TL;DR: It is found that hybridization of surface-bound HS-ssDNA is dependent on surface coverage, and nonspecifically adsorbed DNA is largely removed from the surface.