Proteoglycan neofunctions: Regulation of inflammation and autophagy in cancer biology
TLDR
This minireview will critically discuss the dual role of proteoglycan‐driven inflammation and autophagy in tumor biology, and delineate the potential mechanisms through which soluble extracellular matrix constituents affect the microenvironment associated with inflammatory and neoplastic diseases.Abstract:
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and, as such, are intrinsically involved in cancer initiation and progression. In this minireview, we will address novel functions of biglycan and decorin in inflammation and autophagy, and analyze new emerging signaling events triggered by these proteoglycans, which directly or indirectly modulate these processes. We will critically discuss the dual role of proteoglycan-driven inflammation and autophagy in tumor biology, and delineate the potential mechanisms through which soluble extracellular matrix constituents affect the microenvironment associated with inflammatory and neoplastic diseases.read more
Citations
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The extracellular matrix in tumor progression and metastasis.
Johannes A. Eble,Stephan Niland +1 more
TL;DR: This review focuses on the remodeling of the ECM under the influence of a primary solid tumor mass, primed by soluble factors of the primary tumor, which may be remodeled in a way to facilitate the engraftment of metastasizing cancer cells.
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The extracellular matrix as a multitasking player in disease.
TL;DR: Critical and emerging issues related to matrix assembly in tissues and the multitasking roles for ECM in diseases such as osteoarthritis, fibrosis, cancer, and genetic diseases are presented.
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Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.
Nikos K. Karamanos,Nikos K. Karamanos,Zoi Piperigkou,Zoi Piperigkou,Achilleas D. Theocharis,Hideto Watanabe,Marco Franchi,Stéphanie Baud,Stéphane Brézillon,Martin Götte,Alberto Passi,Davide Vigetti,Sylvie Ricard-Blum,Ralph D. Sanderson,Thomas Neill,Renato V. Iozzo +15 more
TL;DR: The primary goal of this comprehensive review is to summarize major achievements and paradigm-shifting discoveries made on the PG/GAG chemistry-biology axis, focusing on structural variability, structure-function relationships, metabolic, molecular, and epigenetic mechanisms underlying their synthesis.
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Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer.
Anastasia G. Tavianatou,Ilaria Caon,Marco Franchi,Zoi Piperigkou,Zoi Piperigkou,Devis Galesso,Nikos K. Karamanos,Nikos K. Karamanos +7 more
TL;DR: The primary goal of this review is to critically present the importance of HA molecular size on cellular signaling, functional cell properties, and morphology in normal and pathological conditions, including inflammation and cancer.
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A guide to the composition and functions of the extracellular matrix.
Nikos K. Karamanos,Achilleas D. Theocharis,Zoi Piperigkou,Dimitra Manou,Alberto Passi,Spyros S. Skandalis,Demitrios H. Vynios,Véronique Orian-Rousseau,Sylvie Ricard-Blum,Christian E.H. Schmelzer,Christian E.H. Schmelzer,Laurent Duca,Madeleine Durbee,Nikolaos A. Afratis,Linda Troeberg,Marco Franchi,Valentina Masola,Maurizio Onisto +17 more
TL;DR: Extracellular matrix (ECM) is a dynamic 3-dimensional network of macromolecules that provides structural support for the cells and tissues as discussed by the authors, and it plays key regulatory roles since it orchestrates cell signaling, functions, properties and morphology.
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