Journal ArticleDOI
Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: a comparative study.
Gagan Joshi,Janet Wozniak,Carter R. Petty,Carter R. Petty,Mary Kate Martelon,Ronna Fried,Anela Bolfek,Amelia Kotte,Jonathan R. Stevens,Jonathan R. Stevens,Stephannie L. Furtak,Michelle Bourgeois,Janet Caruso,Ashley Caron,Joseph Biederman +14 more
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TLDR
Adults with ASD have high levels of psychiatric comorbidity and dysfunction comparable to a clinically referred population of adults without ASD, and were functionally more impaired with a significant proportion having received both counseling and pharmacotherapy.Abstract:
To systematically examine the patterns of psychiatric comorbidity and functioning in clinically referred adults with autism spectrum disorders (ASD). Psychiatrically referred adults with and without ASD were compared on measures assessing for psychiatric comorbidity and psychosocial functioning. Sixty-three adults with ASD participated in the study (mean age: 29 ± 11 years). Adults with ASD in their lifetime suffered from a higher burden of psychiatric disorders (6 ± 3.4 vs. 3.5 ± 2.7; p < 0.001) including major depressive disorder and multiple anxiety disorders, and were functionally more impaired with a significant proportion having received both counseling and pharmacotherapy. Adults with ASD have high levels of psychiatric comorbidity and dysfunction comparable to a clinically referred population of adults without ASD.read more
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Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder
Charlotte M. Pretzsch,Jan Freyberg,Bogdan Voinescu,David J. Lythgoe,Jamie Horder,Maria Andreina Mendez,Robert Wichers,Laura Ajram,Glynis Ivin,Martin Heasman,Richard A.E. Edden,Steven Williams,Declan G. Murphy,Eileen Daly,Grainne M. McAlonan +14 more
TL;DR: CBD modulates glutamate- GABA systems, but prefrontal-GABA systems respond differently in ASD, and future studies should examine the effects of chronic administration on brain and behaviour, and whether acute brain changes predict longer-term response.
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Group social skills interventions for adults with high-functioning autism spectrum disorders: A systematic review:
Debbie Spain,Sarah H. Blainey +1 more
TL;DR: In this paper, a systematic review was undertaken to investigate the effectiveness of social skills interventions for adults with high-functioning autism spectrum disorders (hf-ASD) -a clinical population who can present with more subtle core deficits, but comparable levels of impairment and secondary difficulties.
Journal ArticleDOI
Self and informant reports of mental health difficulties among adults with autism findings from a long-term follow-up study
TL;DR: The findings highlight the difficulties of assessing mental health problems in adults with autism and the need for appropriately validated measures.
Journal ArticleDOI
A Comparison of Neuroimaging Findings in Childhood Onset Schizophrenia and Autism Spectrum Disorder: A Review of the Literature
TL;DR: The neuroimaging literature supports a neurodevelopmental origin of both ASD and COS and provides evidence for dynamic changes in both conditions that vary across space and time in the developing brain.
Journal ArticleDOI
Healthcare Service Utilization and Cost Among Adults with Autism Spectrum Disorders in a U.S. Integrated Healthcare System
TL;DR: Compared with adults with ADHD, adults with ASD had significantly higher utilization of outpatient visits for primary care (74.2...
References
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