Journal ArticleDOI
Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: a comparative study.
Gagan Joshi,Janet Wozniak,Carter R. Petty,Carter R. Petty,Mary Kate Martelon,Ronna Fried,Anela Bolfek,Amelia Kotte,Jonathan R. Stevens,Jonathan R. Stevens,Stephannie L. Furtak,Michelle Bourgeois,Janet Caruso,Ashley Caron,Joseph Biederman +14 more
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TLDR
Adults with ASD have high levels of psychiatric comorbidity and dysfunction comparable to a clinically referred population of adults without ASD, and were functionally more impaired with a significant proportion having received both counseling and pharmacotherapy.Abstract:
To systematically examine the patterns of psychiatric comorbidity and functioning in clinically referred adults with autism spectrum disorders (ASD). Psychiatrically referred adults with and without ASD were compared on measures assessing for psychiatric comorbidity and psychosocial functioning. Sixty-three adults with ASD participated in the study (mean age: 29 ± 11 years). Adults with ASD in their lifetime suffered from a higher burden of psychiatric disorders (6 ± 3.4 vs. 3.5 ± 2.7; p < 0.001) including major depressive disorder and multiple anxiety disorders, and were functionally more impaired with a significant proportion having received both counseling and pharmacotherapy. Adults with ASD have high levels of psychiatric comorbidity and dysfunction comparable to a clinically referred population of adults without ASD.read more
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Targeting Glia with N-Acetylcysteine Modulates Brain Glutamate and Behaviors Relevant to Neurodevelopmental Disorders in C57BL/6J Mice
Alice M. S. Durieux,Cathy Fernandes,Declan G. Murphy,Marie A. Labouesse,Sandra Giovanoli,Urs Meyer,Urs Meyer,Qi Li,Po-Wah So,Grainne M. McAlonan +9 more
TL;DR: Testing the hypothesis that striatal glutamate levels can be shifted by N-acetylcysteine (NAC), which acts at the cystine-glutamate antiporter of glial cells, found that NAC induced a time-dependent decrease in Striatal glutamate, which recapitulated findings of lowerstriatal glutamate reported in ASD.
Journal ArticleDOI
Viewpoints of adults with and without Autism Spectrum Disorders on public transport
Marita Falkmer,Marita Falkmer,Tania Barnett,Chiara Horlin,Olov Falkmer,Jessica Siljehav,Sofi Fristedt,Hoe Lee,Derserri Yan-Ting Chee,Anders Wretstrand,Torbjörn Falkmer,Torbjörn Falkmer,Torbjörn Falkmer +12 more
TL;DR: There is no research on the opinions of adults with ASD on public transport in Australia, and the viewpoints of individuals with cognitive disabilities are rarely considered.
Journal ArticleDOI
Overlap between autism spectrum disorder and bipolar affective disorder
Norbert Skokauskas,Thomas Frodl +1 more
TL;DR: An accurate detection of co-occurrence of autism spectrum disorder and bipolar affective disorder with BPAD can lead to a more targeted treatment and improve the patients' functioning and quality of life.
Journal ArticleDOI
Diagnostic utility of the autism diagnostic observation schedule in a clinical sample of adolescents and adults
TL;DR: The revised algorithm in the Autism Diagnostic Observation Schedule has good utility when used as part of a comprehensive assessment procedure conducted by an experienced examiner and including information on developmental history.
Journal ArticleDOI
Autism spectrum disorder diagnosis in adults: phenotype and genotype findings from a clinically derived cohort.
Jack F. G. Underwood,Kimberley Kendall,Jennifer Berrett,Catrin Lewis,Richard Anney,Marianne Bernadette van den Bree,Jeremy Hall +6 more
TL;DR: It is suggested that the polygenic load of common ASD-associated variants may be important in conferring risk within the non-intellectually disabled population of adults with ASD.
References
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Emotion Circuits in the Brain
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