Quality of life is significantly impaired in long-term survivors of acute liver failure and particularly in acetaminophen-overdose patients.
Amol S. Rangnekar,Caitlyn Ellerbe,Valerie Durkalski,Brendan M. McGuire,William M. Lee,Robert J. Fontana +5 more
TLDR
Long‐term adult survivors of ALF reported significantly lower quality of life scores than US population controls, possibly because of higher rates of premorbid psychiatric and substance abuse disorders.About:
This article is published in Liver Transplantation.The article was published on 2013-09-01 and is currently open access. It has received 25 citations till now. The article focuses on the topics: Population & acetaminophen overdose.read more
Citations
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Journal ArticleDOI
Drug-induced liver injury
Raúl J. Andrade,Naga Chalasani,Einar Bjornsson,Ayako Suzuki,Ayako Suzuki,Gerd A. Kullak-Ublick,Gerd A. Kullak-Ublick,Paul B. Watkins,Harshad Devarbhavi,Michael Merz,Michael Merz,M. Isabel Lucena,Neil Kaplowitz,Guruprasad P. Aithal +13 more
TL;DR: Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is exposed to toxic doses of some compounds or as an unpredictable event with many drugs in common use as discussed by the authors.
Journal ArticleDOI
Acute liver failure: A curable disease by 2024?
TL;DR: The current understanding of key aspects of the classification, pathophysiology and management of ALF are summarized, and the foreseeable challenges that will need to be addressed for further improvements to be achieved are discussed.
Journal ArticleDOI
Acetaminophen (APAP or N-Acetyl-p-Aminophenol) and Acute Liver Failure
TL;DR: N-acetylcysteine is recommended for all patients with APAP-induced ALF and it reduces mortality and Liver transplantation should be offered early to those who are unlikely to survive based on described prognostic criteria.
Journal ArticleDOI
Severity of chronic Lyme disease compared to other chronic conditions: a quality of life survey
TL;DR: Compared to the general population and patients with other chronic diseases reviewed here, patients with CLD reported significantly lower health quality status, more bad mental and physical health days, a significant symptom disease burden, and greater activity limitations.
Journal ArticleDOI
Two-year outcomes in initial survivors with acute liver failure: results from a prospective, multicentre study.
Robert J. Fontana,Caitlyn Ellerbe,Valerie E. Durkalski,Amol S. Rangnekar,Rajender Reddy,Todd Stravitz,Brendan M. McGuire,Timothy Davern,Adrian Reuben,Iris Liou,Oren K. Fix,Daniel Ganger,Raymond T. Chung,Mike Schilsky,Steven Han,Linda S. Hynan,Corron Sanders,William M. Lee +17 more
TL;DR: The aim of this study was to provide an overview of the 2‐year clinical outcomes among initial survivors and liver transplant recipients that were alive 3 weeks after enrolment in the Acute Liver Failure Study Group (ALFSG).
References
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Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
George Ostapowicz,Robert J. Fontana,Frank V. Schioødt,Anne M. Larson,Timothy J. Davern,Steven Han,Timothy M. McCashland,A. Obaid Shakil,J. Eileen Hay,Linda S. Hynan,Jeffrey S. Crippin,Andres T. Blei,Grace Samuel,Joan S. Reisch,William M. Lee,Raj Santyanarayana,Cary Caldwell,Lawton Shick,Nathan M. Bass,Smita Rouillard,E Atillasoy,Steven L. Flamm,Kent G. Benner,Hugo R. Rosen,Paul Martin,Rise Stribling,Eugene R. Schiff,Maria Torres,Victor J. Navarro,Brendan M. McGuire,Raymond T. Chung,Diane R. Abraczinskas,Jules L. Dienstag +32 more
TL;DR: The primary aim was to compare presenting clinical features and liver transplantation in patients with acute liver failure related to acetaminophen hepatotoxicity, other drugs, indeterminate factors, and other causes.
Journal ArticleDOI
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Anne M. Larson,Julie Polson,Robert J. Fontana,Timothy J. Davern,Ezmina Lalani,Linda S. Hynan,Joan S. Reisch,Frank V. Schiødt,George Ostapowicz,A. Obaid Shakil,William M. Lee +10 more
TL;DR: In conclusion, acetaminophen hepatotoxicity far exceeds other causes of acute liver failure in the United States, and education of patients, physicians, and pharmacies to limit high‐risk use settings is recommended.
Journal ArticleDOI
Health-related quality of life.
TL;DR: Progress in HRQoL assessment in research or clinical monitoring is evolutionary and, arguably, comparable to the increasing use of MRI and immunological markers in quantifying MS severity.
Journal ArticleDOI
Intensive care of patients with acute liver failure: Recommendations of the U.S. Acute Liver Failure Study Group
R. Todd Stravitz,Andreas H. Kramer,Timothy J. Davern,A. Obaid S. Shaikh,Stephen H. Caldwell,Ravindra L. Mehta,Andres T. Blei,Robert J. Fontana,Brendan M. McGuire,Lorenzo Rossaro,Alastair D. Smith,William M. Lee +11 more
TL;DR: Recommendations encompassing specific hematologic, renal, pulmonary, and endocrine complications of acute liver failure patients are provided, including their management during and after orthotopic liver transplantation.
Journal ArticleDOI
Retest reliability of surveillance questions on health related quality of life
TL;DR: Retest reliability of the HRQoL Core is moderate to excellent, and scaling options will require future attention, as will research into appropriate metrics for what constitutes important population group differences and change in HRZoL.
Related Papers (5)
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
George Ostapowicz,Robert J. Fontana,Frank V. Schioødt,Anne M. Larson,Timothy J. Davern,Steven Han,Timothy M. McCashland,A. Obaid Shakil,J. Eileen Hay,Linda S. Hynan,Jeffrey S. Crippin,Andres T. Blei,Grace Samuel,Joan S. Reisch,William M. Lee,Raj Santyanarayana,Cary Caldwell,Lawton Shick,Nathan M. Bass,Smita Rouillard,E Atillasoy,Steven L. Flamm,Kent G. Benner,Hugo R. Rosen,Paul Martin,Rise Stribling,Eugene R. Schiff,Maria Torres,Victor J. Navarro,Brendan M. McGuire,Raymond T. Chung,Diane R. Abraczinskas,Jules L. Dienstag +32 more