Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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TLDR
Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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Same path, different beginnings
Ben W. Dulken,Anne Brunet +1 more
TL;DR: An extensive single-cell transcriptomic collection of over 30,000 cells of the developing hippocampus shows that adult hippocampal neurogenesis follows the same differentiation path as embryonic neurogenisation, but the cell of origin differs.
Exploring Electric Field-Induced Changes in Astrocyte Behavior
TL;DR: This year's research has shaped this year into more than just a research experience, and I wouldn't be where I am today without the chats over frozen yogurt, inevitable arguments, and spontaneous 'adventures' that remind me to enjoy the little things in life.
Dissertation
Functional analysis of transcription factor mScrt2 in cortical neurogenesis.
TL;DR: By promoting the neurogenic mode of RGP-divisions and IPs, the mammalian mScratch2 appears to modulate neuronal differentiation and migration in the developing cortex, with important consequences for the neocortical morphogenesis of the adult brain.
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Glial Cells as the Source of Neurons and Glia in the Developing and Adult CNS
Luísa Pinto,Magdalena Gtz +1 more
TL;DR: The identity, heterogeneity and functions of glial cells in the developing and adult central nervous system (CNS) and the possible mechanisms allowing neurogenic radialglial cells to persist into adulthood in various lineages are considered.
Book
Polybrominated Diphenyl Ethers Disturb Neural Development in Mice and Men
TL;DR: In this paper, the effects of polybrominated diphenyl ethers (PBDEs) on human neurodevelopment in vitro and the mechanisms underlying these changes were investigated.
References
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
TL;DR: It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,Andy Fink,Charmaine Lau,Diane Pham,Ray A. M. Daza,Alessandro Bulfone,Tom Kowalczyk,Robert F. Hevner +7 more
TL;DR: It is shown that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6, a homeodomain transcription factor.
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
TL;DR: Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
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A unified hypothesis on the lineage of neural stem cells.
TL;DR: It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.