Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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TLDR
Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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The origin and development of glial cells in peripheral nerves
Kristjan R. Jessen,Rhona Mirsky +1 more
TL;DR: Embryonic nerves offer a particular opportunity to analyse the early steps of gliogenesis from transient multipotent stem cells, and to understand how this process is integrated with organogenesis of peripheral nerves.
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Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
Fabio Mohn,Michael Weber,Michael Rebhan,Tim Roloff,Jens Richter,Michael B. Stadler,Miriam Bibel,Dirk Schübeler +7 more
TL;DR: A model how de novo DNA methylation and dynamic switches in Polycomb targets restrict pluripotency and define the developmental potential of progenitor cells is suggested.
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Development of the human cerebral cortex: Boulder Committee revisited
TL;DR: Current data on the development of the human cerebral cortex is reviewed and the classical model of how the structure that makes us human is formed is updated.
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Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage
Yechiel Elkabetz,Georgia Panagiotakos,George Al Shamy,Nicholas D. Socci,Viviane Tabar,Lorenz Studer +5 more
TL;DR: It is proposed that R-NSCs represent the first characterized NSC stage capable of responding to patterning cues that direct differentiation toward region-specific neuronal fates, and offer new tools for harnessing the differentiation potential of human ESCs.
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Late-Stage Neuronal Progenitors in the Retina Are Radial Müller Glia That Function as Retinal Stem Cells
TL;DR: It is concluded that zebrafish Müller glia function as multipotent retinal stem cells that generate retinal neurons by homeostatic and regenerative developmental mechanisms.
References
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Identification of radial glial cells within the developing murine central nervous system:studies based upon a new immunohistochemical marker
TL;DR: The robustness of the antigen recognized by RC2 makes this probe a valuable tool to study the morphological transformations of the bipolar radial glia during their mitotic turnover, and it provides a sensitive stain for the study of the organization and the histogenetic role of the overall radial fiber system.
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Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6.
TL;DR: It is shown that neurogenesis becomes fully Pax6-dependent in the neurospheres culture system, independent of the region of origin, and that Pax6 overexpression is sufficient to direct almost all neurosphere-derived cells towards neurogen Genesis.
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Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
Mattias Backman,Ondrej Machon,Line Mygland,Christiaan J. van den Bout,Weimin Zhong,Makoto Mark Taketo,Stefan Krauss +6 more
TL;DR: It is shown that beta-catenin mediated Wnt signals are required to maintain the molecular identity of the pallium by controlling expression of dorsal markers and by suppressing ventral programs from being activated in pallial progenitor cells.
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Neurons from radial glia: the consequences of asymmetric inheritance
TL;DR: Two models that make opposite predictions as to whether the radial glia or nascent neuron inherit the radialglial fiber or the majority of the Numb protein are suggested.
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Asymmetric Distribution of EGFR Receptor during Mitosis Generates Diverse CNS Progenitor Cells
TL;DR: It is found that in mouse embryonic forebrain ventricular and subventricular zones, the EGFR can distribute asymmetrically during mitosis in vivo and in vitro, and this suggests that asymmetric EGFR distribution contributes to forebrain development by creating progenitors with different proliferative, migratory, and differentiation responses to ligand.