Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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TLDR
Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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BMP and LIF signaling coordinately regulate lineage restriction of radial glia in the developing forebrain.
Hedong Li,Martin Grumet +1 more
TL;DR: Results suggest that generation of lineage‐restricted precursors is coordinately regulated by gradients of the secreted factors BMPs and LIF/CNTF during development of dorsal forebrain.
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Adult Human Glioblastomas Harbor Radial Glia-like Cells.
Rong Wang,Roshan Sharma,Xiaojuan Shen,Xiaojuan Shen,Ashley M. Laughney,Kosuke Funato,Philip J. Clark,Philip J. Clark,Monika Shpokayte,Monika Shpokayte,Peter F. Morgenstern,Monalisa Navare,Yichi Xu,Shaghayegh Harbi,Ignas Masilionis,Gouri Nanjangud,Yanhong Yang,Gabriel Duran-Rehbein,Martin Hemberg,Dana Pe'er,Viviane Tabar +20 more
TL;DR: Single-cell RNA sequencing analyses of glioblastoma cells reveal transcriptionally dynamic clusters of RG-like cells that share the profiles of normal human fetal radial glia and that reside in quiescent and cycling states, consistent with the possibility of persistence of RG into adulthood and their involvement in tumor initiation or maintenance.
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Early evolution of radial glial cells in Bilateria.
Conrad Helm,Anett Karl,Patrick Beckers,Sabrina Kaul-Strehlow,Elke Ulbricht,Ioannis Kourtesis,Heidrun Kuhrt,Harald Hausen,Thomas Bartolomaeus,Andreas Reichenbach,Christoph Bleidorn +10 more
TL;DR: It is shown that protostomes also possess radial glia-like cells, which are very likely to be homologous to those of deuterostomes, and antibody staining indicates that the secretory character of radial glial cells is maintained throughout their various evolutionary adaptations.
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Helios Transcription Factor Expression Depends on Gsx2 and Dlx1&2 Function in Developing Striatal Matrix Neurons
Raquel Martín-Ibáñez,Empar Crespo,Miriam Esgleas,Noelia Urbán,Bei Wang,Ronald R. Waclaw,Katia Georgopoulos,Salvador Martinez,Kenneth Campbell,Carlos Vicario-Abejón,Jordi Alberch,Susan Chan,Philippe Kastner,John L.R. Rubenstein,Josep M. Canals +14 more
TL;DR: It is shown that Helios, a member of the Ikaros transcription factor family, is expressed in ectodermal and neuroectodermal-derived tissues and introduced a new transcription factor in the cascade of events that take part of striatal development postulating the existence of at least 4 different neural progenitors in the LGE.
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The insulin-like growth factor system and the fetal brain: effects of poor maternal nutrition
TL;DR: Data showing that this phenomenon applies to pre-natal brain growth and development would make an important contribution to fetal physiology, and studies on the effects of nutrient restriction on the fetal primate brain in relation to activity of the IGF system are needed.
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
TL;DR: It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,Andy Fink,Charmaine Lau,Diane Pham,Ray A. M. Daza,Alessandro Bulfone,Tom Kowalczyk,Robert F. Hevner +7 more
TL;DR: It is shown that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6, a homeodomain transcription factor.
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
TL;DR: Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
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A unified hypothesis on the lineage of neural stem cells.
TL;DR: It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.