Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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TLDR
Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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Journal ArticleDOI
RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons.
Maite Blanco-Urrejola,Adhara Gaminde-Blasco,María Gamarra,Aida de la Cruz,Elena Vecino,Elena Alberdi,Jimena Baleriola,Jimena Baleriola +7 more
TL;DR: A review of the state-of-the-art research on local protein synthesis in neuronal function and dysfunction can be found in this article, where the authors discuss the possibility that local translation in glia and deregulation thereof contributes to neurological and neurodegenerative diseases.
Journal ArticleDOI
Shifts in the vascular endothelial growth factor isoforms result in transcriptome changes correlated with early neural stem cell proliferation and differentiation in mouse forebrain.
Jacob T. Cain,Matthew A. Berosik,Stephanie D. Snyder,Natalie F. Crawford,Shirin I. Nour,Geoffrey J. Schaubhut,Diane C. Darland +6 more
TL;DR: A suite of genes and functional gene networks are identified that can be used to further dissect the role of Vegf in regulating NSC differentiation and downstream consequences for NSC fate decisions.
Journal ArticleDOI
miR-20b/106a modulate Ngn2 gene expression during neural differentiation of human umbilical cord mesenchymal stem cells.
TL;DR: The aim of this study was to perform neural differentiation of mesenchymal stem cells derived from Wharton’s jelly of human umbilical cord and explore the role ofmiR-20b and miR-106a, which may regulate Neurogenin-2 (Ngn2) expression during the neural differentiation.
Book ChapterDOI
Development of the Cerebrospinal Fluid Pathways During Embryonic and Fetal Life in Humans
TL;DR: The genesis of malformation syndromes cannot be understood without a knowledge of the normal steps of development, which contradicts the classical works of human embryology, which were devoted to the analysis of malformations.
Journal ArticleDOI
Enhanced FGFR3 activity in postmitotic principal neurons during brain development results in cortical dysplasia and axonal tract abnormality.
Jui-Yen Huang,Bruna Baumgarten Krebs,Marisha Lynn Miskus,May Lin Russell,Eamonn Patrick Duffy,Jason Michael Graf,Hui-Chen Lu +6 more
TL;DR: GOF disrupts mitosis of radial-glia neural progenitors (RGCs), inside-out radial migration of post-mitotic glutamatergic neurons, and axonal tract projections, and RNA-sequencing analysis of the GOF embryonic cortex reveals significant alterations in several pathways involved in cell cycle regulation andAxonal pathfinding.
References
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Journal ArticleDOI
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
TL;DR: It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,Andy Fink,Charmaine Lau,Diane Pham,Ray A. M. Daza,Alessandro Bulfone,Tom Kowalczyk,Robert F. Hevner +7 more
TL;DR: It is shown that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6, a homeodomain transcription factor.
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
TL;DR: Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
Journal ArticleDOI
A unified hypothesis on the lineage of neural stem cells.
TL;DR: It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.