Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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TLDR
Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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Characterizing the diverse cells that associate with the developing commissures of the zebrafish forebrain
Jake Schnabl,Mackenzie P.H. Litz,Caitlin Schneider,Nadia PenkoffLidbeck,Sarah Bashiruddin,Morgan Schwartz,Kristin Alligood,Michael Barresi +7 more
TL;DR: A comprehensive account of the cellular populations that correlate with the timing and position of commissural axon pathfinding has supported the conceptual modeling and identification of the early forebrain architecture that may be necessary for proper commissure development.
Antonov, A.V., Tetko, I.V., Kosykh, D., Surmeli, D., Mewes, H.-W.: Exploiting scale-free information from expression data for cancer classification. Comput. Biol. Chem. 29, 288-293 (2005)
R. Arnold,Christian Lemer,J. Richelles,Shoshana J. Wodak,J. Garcia-Martinez,J. E. Perez-Ortin,H. Michael,Andreas Kaps,Emmanuel Talla +8 more
Journal ArticleDOI
Adult Endogenous Dopaminergic Neuroregeneration Against Parkinson’s Disease: Ideal Animal Models?
Yuganthini Vijayanathan,Yuganthini Vijayanathan,Siong Meng Lim,Maw Pin Tan,Fei Ting Lim,Abu Bakar Abdul Majeed,Kalavathy Ramasamy +6 more
TL;DR: The present review highlights the advantages and disadvantages of both mammalian and non-mammalian animal models that can be essentially used to study the potential of endogenous DpN regeneration against PD.
Dissertation
Regulation of neurogenesis in the vertebrate CNS
TL;DR: The role of Sox21 is investigated during the progression of neurogenesis in the chick spinal cord and it is found that Sox1-3 proteins have the ability to maintain progenitor cells in an undifferentiated state and suppress neuronal differentiation.
References
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
TL;DR: It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,Andy Fink,Charmaine Lau,Diane Pham,Ray A. M. Daza,Alessandro Bulfone,Tom Kowalczyk,Robert F. Hevner +7 more
TL;DR: It is shown that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6, a homeodomain transcription factor.
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
TL;DR: Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
Journal ArticleDOI
A unified hypothesis on the lineage of neural stem cells.
TL;DR: It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.