Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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TLDR
Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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The function of connexin43 in neuronal migration and cortical development
TL;DR: It is suggested that children under the age of five should be supervised by an adult rather than a stranger, as is the case with children aged under five and children under six.
Dissertation
Régulation de l’aromatase B dans les cellules gliales radiaires dans le cerveau du poisson zèbre (Danio rerio) et rôles potentiels dans la neurogénèse adulte
TL;DR: Nous mettons en evidence that des androgenes peuvent reguler l’aroB, via les recepteurs aux œstrogenes (ERs) via the forte activite neurogenique chez le poisson zebre adulte.
Journal ArticleDOI
Conditioned medium of E17 rat brain cells induced differentiation of primary colony of mice blastocyst into neuron-like cells.
Vista Budiariati,Ratih Rinendyaputri,Ariyani Noviantari,Noer Muhammad Dliyaul Haq,Dwi Budiono,Diah Nugrahani Pristihadi,Berry Juliandi,Mokhamad Fahrudin,Arief Boediono +8 more
TL;DR: In this paper, the effects of conditioned medium derived from E17 rat brain cells on cells with pluripotent properties were examined, and the morphological changes in the colonies were examined.
DissertationDOI
Characterization of neural progenitor/stem cells derived from human embryonic stem cells
TL;DR: In this paper, the neural differentiation process of human embryonic stem cells (hESCs) has been investigated using an established protocol, identifying characteristics associated with each stage of the differentiation and explored possible signalling pathways underlying these dynamic changes.
References
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
TL;DR: It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,Andy Fink,Charmaine Lau,Diane Pham,Ray A. M. Daza,Alessandro Bulfone,Tom Kowalczyk,Robert F. Hevner +7 more
TL;DR: It is shown that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6, a homeodomain transcription factor.
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
TL;DR: Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
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A unified hypothesis on the lineage of neural stem cells.
TL;DR: It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.