Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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Dynamic distribution and stem cell characteristics of Sox1-expressing cells in the cerebellar cortex.
Joelle Alcock,Virginie Sottile +1 more
TL;DR: The results show that the Bergmann glia population expresses Sox1 during cerebellar development, and that these cells can be isolated and show stem cell characteristics in vitro, suggesting that they could hold a broader potential than previously thought.
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Tangentially Migrating Transient Glutamatergic Neurons Control Neurogenesis and Maintenance of Cerebral Cortical Progenitor Pools
Anne Teissier,Ronald R. Waclaw,Amelie Griveau,Amelie Griveau,Kenneth Campbell,Alessandra Pierani +5 more
TL;DR: It is shown that a transient population of glutamatergic neurons, the cortical plate (CP) transient neurons, migrates from the ventral pallium (VP) over long distances and participate in neocortical development, and appears to participate in the extrinsic control of cortical neuronal numbers.
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Glycosignaling in neural stem cells: involvement of glycoconjugates in signal transduction modulating the neural stem cell fate.
Robert K. Yu,Makoto Yanagisawa +1 more
TL;DR: The roles of glycoconjugates in regulating the fate of NSCs and in supporting the underlying signal transduction mechanisms are discussed.
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MicroRNA‐independent functions of DGCR8 are essential for neocortical development and TBR1 expression
Federica Marinaro,Matteo Jacopo Marzi,Nadin Hoffmann,Hayder Amin,Roberta Pelizzoli,Francesco Niola,Francesco Nicassio,Davide De Pietri Tonelli +7 more
TL;DR: The data suggest that the Microprocessor complex, with DROSHA and DGCR8 as core components, directly regulates the Tbr1 transcript, containing evolutionarily conserved hairpins that resemble miRNA precursors, independently of miRNAs.
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Bergmann glia as putative stem cells of the mature cerebellum.
TL;DR: It is shown that a discrete cell population of the cerebellar cortex, the Bergmann glia, shares the expression of key molecular markers with neural stem cells, and the hypothesis that the Bergman glia may represent a novel and abundant stem cell population in the mature cerebellum is examined.
References
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
TL;DR: It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,Andy Fink,Charmaine Lau,Diane Pham,Ray A. M. Daza,Alessandro Bulfone,Tom Kowalczyk,Robert F. Hevner +7 more
TL;DR: It is shown that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6, a homeodomain transcription factor.
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
TL;DR: Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
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A unified hypothesis on the lineage of neural stem cells.
TL;DR: It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.