Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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TLDR
Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia
Kei Ichiro Takase,Hiroshi Shigeto,Satoshi O. Suzuki,Hitoshi Kikuchi,Yasumasa Ohyagi,Jun Ichi Kira +5 more
TL;DR: A novel rat model is created by freeze lesioning during the late embryonic stage to verify whether FCD influences seizure activities.
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The receptor for Granulocyte-colony stimulating factor (G-CSF) is expressed in radial glia during development of the nervous system
TL;DR: The data imply that in addition to the function of G-CSF and its receptor in adult neurogenesis, this system also has a role in embryonic Neurogenesis and nervous system development.
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Cell-replacement therapy and neural repair in the retina
TL;DR: Recent advances in the development of cell-replacement approaches for the treatment of currently incurable degenerative retinal diseases are discussed.
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In vitro recapitulation of neural development using embryonic stem cells: from neurogenesis to histogenesis.
Keiko Muguruma,Yoshiki Sasai +1 more
TL;DR: The ability of ES cells to generate not only specific neuronal populations but also functional neural tissues by recapitulating microenvironments in early mammalian development is reviewed.
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Neuron–Astroglial Interactions in Cell-Fate Commitment and Maturation in the Central Nervous System
Joice Stipursky,Tania Cristina Leite de Sampaio e Spohr,Vivian de Oliveira Sousa,Flávia Carvalho Alcantara Gomes +3 more
TL;DR: It is argued that the functional architecture of the brain depends on an intimate neuron-glia partnership, by briefly discussing the emerging view of how neuron-astrocyte dysfunctions might be associated with neurodegenerative diseases and neurological disorders.
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
TL;DR: It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,Andy Fink,Charmaine Lau,Diane Pham,Ray A. M. Daza,Alessandro Bulfone,Tom Kowalczyk,Robert F. Hevner +7 more
TL;DR: It is shown that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6, a homeodomain transcription factor.
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
TL;DR: Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
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A unified hypothesis on the lineage of neural stem cells.
TL;DR: It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.