Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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TLDR
Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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The Tg(ccnb1:EGFP) transgenic zebrafish line labels proliferating cells during retinal development and regeneration
Sean C. Kassen,Ryan Thummel,Christopher T. Burket,Laura A. Campochiaro,Molly J. Harding,David R. Hyde +5 more
TL;DR: The spatial and temporal patterning of EGFP expression in the Tg(ccnb1:EGFP)nt18 line directly reflects the known locations of proliferating cells in the zebrafish retina, making it a useful marker to study the transient nature of neuronal progenitor cells during the development and regeneration of the zbrafish retina.
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Recent molecular approaches to understanding astrocyte function in vivo.
TL;DR: Recent developments in innovative and powerful molecular approaches, including knockout mouse models, transgenic mice models, and astrocyte-targeted gene transfer/expression, are summarized, which have led to advances in understanding astroCyte biology in vivo that were heretofore inaccessible to experimentation.
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The POU homeobox protein Oct-1 regulates radial glia formation downstream of Notch signaling.
TL;DR: It is shown that Notch signaling promotes Xenopus radial glia formation and that the Notch activation is sufficient for radial glial formation prior to neural tube closure and that Oct-1 is sufficient and necessary for radialglia formation.
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Basal progenitor cells in the embryonic mouse thalamus - their molecular characterization and the role of neurogenins and Pax6
TL;DR: The existence of a unique and significant population of basal progenitor cells in the thalamus is established and their dependence on neurogenins and Pax6 is established, indicating that, similar to the neocortex and ventral telencephalon, theThalamus has a distinct subventricular zone.
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Temporal and epigenetic regulation of neurodevelopmental plasticity
TL;DR: It is proposed that understanding the processes of epigenetic programming within the neural lineage is likely to lead to the development of more rationale strategies for cell reprogramming that may be used to expand the developmental potential of otherwise restricted progenitor populations.
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
TL;DR: It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,Andy Fink,Charmaine Lau,Diane Pham,Ray A. M. Daza,Alessandro Bulfone,Tom Kowalczyk,Robert F. Hevner +7 more
TL;DR: It is shown that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6, a homeodomain transcription factor.
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
TL;DR: Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
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A unified hypothesis on the lineage of neural stem cells.
TL;DR: It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.