Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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TLDR
Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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The Indispensable Roles of Microglia and Astrocytes during Brain Development
TL;DR: A better understanding of the origin, differentiation process and developmental functions of microglia and astrocytes will help to fully appreciate their role both in the developing as well as in the adult brain, in health and disease.
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Role of intermediate progenitor cells in cerebral cortex development.
TL;DR: It is proposed that regulation of IPC genesis and amplification across developmental stages and regional subdivisions modulates laminar neurogenesis and contributes to the cytoarchitectonic differentiation of cortical areas.
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miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex
Davide De Pietri Tonelli,Jeremy N. Pulvers,Christiane Haffner,Elizabeth P. Murchison,Gregory J. Hannon,Wieland B. Huttner +5 more
TL;DR: The results support the emerging concept that progenitors are less dependent on miRNAs than their differentiated progeny, and raise interesting perspectives as to the expansion of somatic stem cells.
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Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain
TL;DR: The level of adult neurogenesis in vertebrates correlates with the capacity to regenerate injury, for example fish and amphibians exhibit the most widespread adult Neurogenesis and also the greatest capacity to regeneration central nervous system injuries.
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Neural stem cells in mammalian development.
TL;DR: Advances challenge the traditional perceptions of glia and stem cells, and provide the foundation for understanding the molecular basis of mammalian NSC behavior.
References
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
TL;DR: It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,Andy Fink,Charmaine Lau,Diane Pham,Ray A. M. Daza,Alessandro Bulfone,Tom Kowalczyk,Robert F. Hevner +7 more
TL;DR: It is shown that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6, a homeodomain transcription factor.
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
TL;DR: Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
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A unified hypothesis on the lineage of neural stem cells.
TL;DR: It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.