Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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TLDR
Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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Neural lineage development in the rhesus monkey with embryonic stem cells
TL;DR: It was revealed that neural differentiation likely progresses in a sequential lineage restriction pathway from neuroepithelial stem/progenitor cells to neurons and glia via RG and intermediate precursors: neuronal precursor and glial progenitors.
Dissertation
Physiopathologie des malformations du développement cortical associées à des mutations du gène tubuline β3
TL;DR: L’inactivation of Tubb3 entraine un defaut de migration drastique : the majorite des cellules electroporees sont presentes dans la zone sous ventriculaire et the zone intermediaire, and une augmentation du nombre de cellules rondes ne presentant pas ou peu of processus.
DissertationDOI
Mouse embryonic stem cells as a new discovery tool in neurobiology
TL;DR: The results suggest that Galectin-1 acts as an effector of neuronal degeneration downstream of p75NTR, both in vitro and in vivo, which illustrates the advantages of working with homogenous cell populations derived from ES cells.
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Choline acetyltransferase expressed by radial neuroglia cells in the development of elencephalon: A validated study
TL;DR: It is confirmed using by flow cytometer that embryogenesis time of cholinergic neuron was at E12, and shown the population of cells in VZ of dorsal telencephalon of E14 rat co-expressed vimentin and ChAT through immunohistochemistry double staining.
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From stem and progenitor cells to neurons in the developing neocortex: key differences among hominids
TL;DR: In this article, the authors compare the neural stem and progenitor cells (NSPCs) and neurons of hominids and highlight that the regulation of the timing of these processes is emerging as a general foundational difference in the development of the neocortex of the human brain.
References
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
TL;DR: It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,Andy Fink,Charmaine Lau,Diane Pham,Ray A. M. Daza,Alessandro Bulfone,Tom Kowalczyk,Robert F. Hevner +7 more
TL;DR: It is shown that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6, a homeodomain transcription factor.
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
TL;DR: Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
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A unified hypothesis on the lineage of neural stem cells.
TL;DR: It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.