Radial glial cells: defined and major intermediates between embryonic stem cells and CNS neurons
Magdalena Götz,Yves-Alain Barde +1 more
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TLDR
Evidence for the distinct "glial" nature of radial glial cells is reviewed and progenitors with clear glial antigenic characteristics act as cellular intermediates are contrasted with the neuroepithelial cells.About:
This article is published in Neuron.The article was published on 2005-05-05 and is currently open access. It has received 333 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurogenesis.read more
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Proliferation, migration and differentiation in juvenile and adult Xenopus laevis brains
TL;DR: In situ hybridization/immunocytochemistry double-labeling techniques demonstrate for the first time in post-metamorphic frog brain that the proliferative cells are localized in very close vivinity to the radial glial cells, progenitor cells that are identified in the ventricular layer using classical molecular markers.
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Erratum on: Neurogenesis in the embryonic and adult brain: same regulators, different roles
TL;DR: A tantalizing hypothesis for the mechanism underlying Notch function in stem cell quiescence comes from embryonic data showing that the levels of Hes proteins and proneural bHLHs oscillate in neural precursor cells, suggesting that Ascl1 has indeed a dynamic expression in proliferating NSCs.
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Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning.
Isabelle A. Bouhon,Alexis J Joannides,Hidemasa Kato,Siddharthan Chandran,Nicholas D. Allen,Nicholas D. Allen +5 more
TL;DR: It is demonstrated that the ability to pattern embryonic stem cell‐derived neural progenitors is temporally restricted and shown that the loss of responsiveness to morphogenetic cues correlates with constitutive expression of the basic helix‐loop‐helix transcription factors Olig2 and Mash1, epidermal growth factor receptor, and vimentin and parallels the onset of gliogenesis.
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Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.
TL;DR: A novel intracellular positive feedback loop connects FbW7 and Notch: while Fbw7 down-regulates the stability of NICD protein, it is also itself transcriptionally down-regulated by NICD target Hes5.
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Harmine stimulates proliferation of human neural progenitors.
Vanja Dakic,Renata de Moraes Maciel,Hannah Drummond,Juliana M. Nascimento,Pablo Trindade,Stevens K. Rehen +5 more
TL;DR: Findings show that harmine enhances proliferation of hNPCs and suggest that inhibition of DYRK1A may explain its effects upon proliferation in vitro and antidepressant effects in vivo.
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
TL;DR: It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Chris Englund,Andy Fink,Charmaine Lau,Diane Pham,Ray A. M. Daza,Alessandro Bulfone,Tom Kowalczyk,Robert F. Hevner +7 more
TL;DR: It is shown that the transition from radial glia to intermediate progenitor cell is associated with upregulation of Tbr2, a T-domain transcription factor, and downregulation of Pax6, a homeodomain transcription factor.
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
TL;DR: Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
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A unified hypothesis on the lineage of neural stem cells.
TL;DR: It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.