Journal ArticleDOI
Recurrence Pattern Analysis of Primary Glioblastoma.
Marion Rapp,Jessica Baernreuther,Bernd Turowski,Hans-Jakob Steiger,Michael Sabel,Marcel A. Kamp +5 more
Reads0
Chats0
TLDR
Despite complete resection of contrast-enhancing tumor, most recurrences occurred locally, so patients with distant tumor recurrence demonstrated increased progression-free survival, and may need to shift toward a more aggressive supramarginal resection to gain local control.About:
This article is published in World Neurosurgery.The article was published on 2017-07-01. It has received 57 citations till now.read more
Citations
More filters
Journal ArticleDOI
Frontiers in the treatment of glioblastoma: Past, present and emerging.
Taskeen Iqbal Janjua,Prarthana V. Rewatkar,Aria Ahmed-Cox,Iqira Saeed,Friederike M. Mansfeld,Ritu Kulshreshtha,Tushar Kumeria,David S. Ziegler,Maria Kavallaris,Roberta Mazzieri,Amirali Popat +10 more
TL;DR: In this paper, a comprehensive review evaluates the current and emerging therapies including those in clinical trials that may potentially improve both targeted delivery of therapeutics directly to the tumour site and the development of agents that may specifically target GBM.
Journal ArticleDOI
The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and as Orthotopic Xenografts.
TL;DR: It is indicated that VX-984 enhances the radiosensitivity of brain tumor xenografts and suggest that it may be of benefit in the therapeutic management of GBM.
Journal ArticleDOI
The Roles of miRNA in Glioblastoma Tumor Cell Communication: Diplomatic and Aggressive Negotiations.
Andrei Buruiana,Ștefan Ioan Florian,Alexandru Ioan Florian,Teodora-Larisa Timiș,Carmen Mihaela Mihu,Maria Miclăuș,Sergiu Oșan,Iona Hrapșa,Radu Constantin Cataniciu,Marius Farcaș,Sergiu Șușman +10 more
TL;DR: A bidirectional miR-21 exchange increases STAT3 activity in GBM cells and macrophages, promoting invasion, proliferation, angiogenesis, and resistance to treatment in glioblastoma.
Journal ArticleDOI
Applications of radiomics and machine learning for radiotherapy of malignant brain tumors
Martin Kocher,Martin Kocher,Maximilian I. Ruge,Norbert Galldiks,Norbert Galldiks,Philipp Lohmann,Philipp Lohmann +6 more
TL;DR: Clinical application of automated image analyses based on radiomics and artificial intelligence has a great potential for improving radiotherapy in patients with malignant brain tumors.
Journal ArticleDOI
Supratotal resection in glioma: a systematic review
TL;DR: The literature suggests insufficient evidence for carte blanche application of supratotal resection, particularly in lower-grade gliomas where neurological deficits can result in long-term disability.
References
More filters
Journal ArticleDOI
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Roger Stupp,Warren P. Mason,Martin J. van den Bent,Michael Weller,Barbara Fisher,Martin J.B. Taphoorn,Karl Belanger,Alba A. Brandes,Christine Marosi,Ulrich Bogdahn,Jürgen Curschmann,Robert C. Janzer,Samuel K. Ludwin,Thierry Gorlia,Anouk Allgeier,Denis Lacombe,J. Gregory Cairncross,Elizabeth Eisenhauer,René O. Mirimanoff +18 more
TL;DR: The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity.
Journal ArticleDOI
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
Roger Stupp,Monika E. Hegi,Warren P. Mason,Martin J. van den Bent,Martin J.B. Taphoorn,Robert C. Janzer,Samuel K. Ludwin,Anouk Allgeier,Barbara Fisher,Karl Belanger,Peter Hau,Alba A. Brandes,J.M.M. Gijtenbeek,Christine Marosi,Charles J. Vecht,Karima Mokhtari,Pieter Wesseling,Salvador Villà,Elizabeth Eisenhauer,Thierry Gorlia,Michael Weller,Denis Lacombe,J. Gregory Cairncross,René-Olivier Mirimanoff +23 more
TL;DR: Benefits of adjuvant temozolomide with radiotherapy lasted throughout 5 years of follow-up, and a benefit of combined therapy was recorded in all clinical prognostic subgroups, including patients aged 60-70 years.
Journal ArticleDOI
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Journal ArticleDOI
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Walter Stummer,Uwe Pichlmeier,Thomas Meinel,Otmar D. Wiestler,Friedhelm E. Zanella,Hans-Jürgen Reulen +5 more
TL;DR: Tumour fluorescence derived from 5-aminolevulinic acid enables more complete resections of contrast-enhancing tumour, leading to improved progression-free survival in patients with malignant glioma.
Journal ArticleDOI
Assumptions in the radiotherapy of glioblastoma
Fred H. Hochberg,Amy A. Pruitt +1 more
TL;DR: CT scan accuracy may permit smaller-field and higher-dose irradiation therapy for glioblastoma, and current radiation doses would appear to be inadequate for therapy of the primary tumor.
Related Papers (5)
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Roger Stupp,Warren P. Mason,Martin J. van den Bent,Michael Weller,Barbara Fisher,Martin J.B. Taphoorn,Karl Belanger,Alba A. Brandes,Christine Marosi,Ulrich Bogdahn,Jürgen Curschmann,Robert C. Janzer,Samuel K. Ludwin,Thierry Gorlia,Anouk Allgeier,Denis Lacombe,J. Gregory Cairncross,Elizabeth Eisenhauer,René O. Mirimanoff +18 more
Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group
Patrick Y. Wen,David R. Macdonald,David A. Reardon,Timothy F. Cloughesy,A. Gregory Sorensen,Evanthia Galanis,John DeGroot,Wolfgang Wick,Mark R. Gilbert,Andrew B. Lassman,Christina Tsien,Tom Mikkelsen,Eric T. Wong,Marc C. Chamberlain,Roger Stupp,Kathleen R. Lamborn,Michael A. Vogelbaum,Martin J. van den Bent,Susan M. Chang +18 more