Redox characteristics of the eukaryotic cytosol.
TLDR
In the present review, recent progress in the understanding of the cytosolic thiol-disulfide redox metabolism and novel analytical approaches to studying cytosol redox properties are discussed.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2008-04-01 and is currently open access. It has received 186 citations till now. The article focuses on the topics: RoGFP & Cellular compartment.read more
Citations
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Glutathione Homeostasis and Functions: Potential Targets forMedical Interventions
TL;DR: The principal mechanisms of the protective role of GSH against reactive species and electrophiles are characterized and a hypothesis for investigation of the physiology and biochemistry of glutathione is provided with a focus on human and animal health.
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Block Copolymer Micelles in Nanomedicine Applications.
TL;DR: By shaping these features, polymeric micelles have been propitious for delivering a wide range of therapeutics through effective sensing of targets in the body and adjustment of their properties in response to particular stimuli, modulating the activity of the loaded drugs at the targeted sites, even at the subcellular level.
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Photopharmacology: Beyond Proof of Principle
TL;DR: This Perspective presents the reader with the current state and outlook on photopharmacology, in particular the principles behind photoregulation of bioactivity, the challenges of molecular design, and the possible therapeutic scenarios are discussed.
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The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae
TL;DR: The progress in understanding the response of the yeast Saccharomyces cerevisiae to two important environmental stresses: heat shock and oxidative stress is reviewed.
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The human PDI family: Versatility packed into a single fold
TL;DR: The diversity of cellular functions described for the human PDIs is explored, which emphasizes as much their differences as their similarities, and underlines the versatility of the thioredoxin fold.
References
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Mitochondrial formation of reactive oxygen species.
TL;DR: This review describes the main mitochondrial sources of reactive species and the antioxidant defences that evolved to prevent oxidative damage in all the mitochondrial compartments and discusses various physiological and pathological scenarios resulting from an increased steady state concentration of mitochondrial oxidants.
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Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
TL;DR: Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.
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Protein Oxidation in Aging, Disease, and Oxidative Stress
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Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.