Reduction of trans-4,5-Dihydroxy-1,2-dithiane by Cellular Oxidoreductases Activates gadd153/chop andgrp78 Transcription and Induces Cellular Tolerance in Kidney Epithelial Cells
TLDR
Activation of stress genes and induction of cellular tolerance by DTTox is mediated by a novel mechanism involving cellular oxidoreductases.About:
This article is published in Journal of Biological Chemistry.The article was published on 1997-08-29 and is currently open access. It has received 39 citations till now. The article focuses on the topics: Dithiothreitol & Glutathione.read more
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Endoplasmic Reticulum Chaperones GRP78 and Calreticulin Prevent Oxidative Stress, Ca2+ Disturbances, and Cell Death in Renal Epithelial Cells
Hong Liu,Russell C. Bowes,Bob van de Water,Bob van de Water,Christopher Sillence,J. Fred Nagelkerke,James L. Stevens +6 more
TL;DR: The data support a model in which induction of ER stress proteins prevents disturbances of intracellular Ca2+ homeostasis, thus uncoupling toxicant exposure from oxidative stress and cell death, and support the role of ER chaperones of the GRP family in tolerance.
Journal ArticleDOI
Homocysteine-Induced Endoplasmic Reticulum Stress and Growth Arrest Leads to Specific Changes in Gene Expression in Human Vascular Endothelial Cells
P. A. Outinen,Sudesh K. Sood,S. I. Pfeifer,Sushmita Pamidi,Thomas J. Podor,Jun Li,J. I. Weitz,Richard C. Austin +7 more
TL;DR: It is demonstrated that homocysteine causes endoplasmic reticulum (ER) stress and growth arrest in human umbilical vein endothelial cells (HUVEC), and cDNA microarrays are screened using radiolabeled cDNA probes generated from mRNA derived from HUVEC, showing correlation between expression profiles determined by this method and by Northern blotting.
Journal ArticleDOI
A DNA expression array to detect toxic stress response in European flounder (Platichthys flesus).
TL;DR: This study provides a link between traditional single-gene biomarker studies and the emerging field of eco-toxicogenomics, demonstrating the utility of microarray studies on environmentally sampled, non-model organisms.
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Endoplasmic Reticulum Stress Proteins Block Oxidant-induced Ca2+ Increases and Cell Death
TL;DR: Ca2+ plays an important role in TBHP-induced cell death in renal epithelial cells, and the ER is an important regulator of cellular Ca2+ homeostasis during oxidative stress.
Journal ArticleDOI
The Endoplasmic Reticulum in Xenobiotic Toxicity
TL;DR: The importance of the ER in molecular events leading to cell death following xenobiotic exposure is discussed and data showing that the ER is important in both renal and hepatic toxicity will be discussed.
References
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Methods of Enzymatic Analysis
TL;DR: Methods of enzymatic analysis, Methods of enzymes analysis, the authors, Methods of enzyme analysis, enzymatics, methods of enzymes, and methods of analysis, method of enzymes.
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Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
Jozef Sedlak,Raymond H. Lindsay +1 more
TL;DR: A simple spectrophotometric method for the routine concomitant determination of sulfhydryl groups in PB- SH, NP-SH, and T-SH fractions in various tissues is reported.
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Protein folding in the cell.
TL;DR: Folding and assembly of polypeptides in vivo involves other proteins, many of which belong to families that have been highly conserved during evolution.
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Oxidized redox state of glutathione in the endoplasmic reticulum
TL;DR: Results suggest that the demonstrated preferential transport of GSSG compared to GSH into the ER lumen may contribute to this redox compartmentation.
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Redox regulation of fos and jun DNA-binding activity in vitro
TL;DR: DNA binding of the Fos-Jun heterodimer was modulated by reduction-oxidation of a single conserved cysteine residue in the DNA-binding domains of the two proteins, suggesting that transcriptional activity mediated by AP-1 binding factors may be regulated by a redox mechanism.