Regional susceptibility to dose-dependent white matter damage after brain radiotherapy.
M. Connor,Roshan Karunamuni,Carrie R. McDonald,Tyler M. Seibert,Nathan S. White,Vitali Moiseenko,Hauke Bartsch,Nikdokht Farid,Joshua M. Kuperman,Anitha Priya Krishnan,Anders M. Dale,Jona A. Hattangadi-Gluth +11 more
TLDR
The corpus callosum, cingulum bundle, and fornix show the most prominent dose-dependent changes following RT, and future studies examining correlation with cognitive functioning and potential avoidance of critical white matter regions are warranted.About:
This article is published in Radiotherapy and Oncology.The article was published on 2017-05-01 and is currently open access. It has received 86 citations till now. The article focuses on the topics: White matter & Fractional anisotropy.read more
Citations
More filters
Journal ArticleDOI
Predicting late magnetic resonance image changes in glioma patients after proton therapy.
J. Eulitz,Esther G.C. Troost,Felix Raschke,E. Schulz,B. Lutz,Almut Dutz,Steffen Löck,Patrick Wohlfahrt,Wolfgang Enghardt,C. Karpowitz,Mechthild Krause,Armin Lühr +11 more
TL;DR: Proton beam therapy (PBT) is expected to reduce radiation-induced side-effects compared to state-of-the-art photon treatments as the physical properties of protons offer the possibility to spare no energy.
Journal ArticleDOI
Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma.
Theresa A Lawrie,David C Gillespie,Therese Dowswell,Jonathan Evans,Sara Erridge,Luke Vale,Ashleigh Kernohan,Robin Grant +7 more
TL;DR: The long-term neurocognitive and other side effects of radiotherapy (with or without chemotherapy) compared with no radiotherapy, or different types of radi therapy, among people with glioma are evaluated and evidence was of low to very low certainty.
Journal ArticleDOI
Cognitive impairment and morphological changes after radiation therapy in brain tumors: A review
J. Jacob,Thomas Durand,Loïc Feuvret,Jean-Jacques Mazeron,Jean-Yves Delattre,Khê Hoang-Xuan,Dimitri Psimaras,Hassen Douzane,Monica Ribeiro,Laurent Capelle,Alexandre Carpentier,Damien Ricard,Philippe Maingon +12 more
TL;DR: The aims of this literature review are to report the main brain areas involved in cognitive adverse effects induced by radiotherapy, to better understand brain radiosensitivity and to describe potential future improvements.
Journal ArticleDOI
Normal tissue complication probability (NTCP) models for modern radiation therapy
TL;DR: Issues relevant to hypofractionated stereotactic body RT and ion beam therapy are critically reviewed and a new phenomenological approach to predict RIM is suggested.
Journal ArticleDOI
Identifying early diffusion imaging biomarkers of regional white matter injury as indicators of executive function decline following brain radiotherapy: A prospective clinical trial in primary brain tumor patients.
Kathryn R. Tringale,Tanya T. Nguyen,Naeim Bahrami,Deborah C. Marshall,Kelly M. Leyden,Roshan Karunamuni,Tyler M. Seibert,M.K. Gorman,M. Connor,Jeffrey Burkeen,David Piccioni,Nikdokht Farid,Jona A. Hattangadi-Gluth,Carrie R. McDonald +13 more
TL;DR: Early microstructural loss within AC SWM represents an important biomarker for EF decline, and dose reduction in this region may represent a possibility for cognitive preservation for patients receiving radiotherapy.
References
More filters
Journal ArticleDOI
Fitting Linear Mixed-Effects Models Using lme4
TL;DR: In this article, a model is described in an lmer call by a formula, in this case including both fixed-and random-effects terms, and the formula and data together determine a numerical representation of the model from which the profiled deviance or the profeatured REML criterion can be evaluated as a function of some of model parameters.
Journal ArticleDOI
Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain.
Bruce Fischl,David H. Salat,Evelina Busa,Marilyn S. Albert,Megan E. Dieterich,Christian Haselgrove,Andre van der Kouwe,Ronald J. Killiany,David N. Kennedy,Shuna Klaveness,Albert Montillo,Nikos Makris,Bruce R. Rosen,Anders M. Dale +13 more
TL;DR: In this paper, a technique for automatically assigning a neuroanatomical label to each voxel in an MRI volume based on probabilistic information automatically estimated from a manually labeled training set is presented.
Journal ArticleDOI
Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data.
Stephen M. Smith,Mark Jenkinson,Heidi Johansen-Berg,Daniel Rueckert,Thomas E. Nichols,Clare E. Mackay,Kate E. Watkins,Olga Ciccarelli,M Z Cader,Paul M. Matthews,Timothy E.J. Behrens +10 more
TL;DR: TBSS aims to improve the sensitivity, objectivity and interpretability of analysis of multi-subject diffusion imaging studies by solving the question of how to align FA images from multiple subjects in a way that allows for valid conclusions to be drawn from the subsequent voxelwise analysis.
Journal ArticleDOI
Dysmyelination Revealed through MRI as Increased Radial (but Unchanged Axial) Diffusion of Water
Sheng-Kwei Song,Shu-Wei Sun,Shu-Wei Sun,Michael J. Ramsbottom,Chen Chang,John H. Russell,Anne H. Cross +6 more
TL;DR: The use of magnetic resonance diffusion tensor imaging to quantify the effect of dysmyelination on water directional diffusivities in brains of shiverer mice in vivo suggests that changes in lambda(perpendicular) and lambda(parallel) may potentially be used to differentiate myelin loss versus axonal injury.
Journal ArticleDOI
Diffusion Tensor Imaging of the Brain
TL;DR: Diffusion tensor imaging (DTI) is a promising method for characterizing microstructural changes or differences with neuropathology and treatment and the biological mechanisms, acquisition, and analysis of DTI measurements are addressed.