Regulation of Heparin-Binding EGF-Like Growth Factor by miR-212 and Acquired Cetuximab-Resistance in Head and Neck Squamous Cell Carcinoma
Hiromitsu Hatakeyama,Haixia Cheng,Pamela S. Wirth,Ashley Counsell,S. Marcrom,Carey Burton Wood,Paula R. Pohlmann,Jill Gilbert,Barbara A. Murphy,Wendell G. Yarbrough,Deric L. Wheeler,Paul M. Harari,Yan Guo,Yu Shyr,Robbert J.C. Slebos,Christine H. Chung +15 more
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TLDR
Increased expression of HB-EGF due to down-regulation of miR-212 is a possible mechanism of cetuximab resistance and the combination of EGFR ligand inhibitors or miR modulators with cetUXimab may improve the clinical outcome of cETuximAB therapy in HNSCC.Abstract:
Background
We hypothesized that chronic inhibition of epidermal growth factor receptor (EGFR) by cetuximab, a monoclonal anti-EGFR antibody, induces up-regulation of its ligands resulting in resistance and that microRNAs (miRs) play an important role in the ligand regulation in head and neck squamous cell carcinoma (HNSCC).read more
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Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
Sandra Misale,Rona Yaeger,Sebastijan Hobor,Elisa Scala,Manickam Janakiraman,David Liska,Emanuele Valtorta,Roberta Schiavo,Michela Buscarino,Giulia Siravegna,Katia Bencardino,Andrea Cercek,Chin Tung Chen,Silvio Veronese,Carlo Zanon,Andrea Sartore-Bianchi,Marcello Gambacorta,Margherita Gallicchio,Efsevia Vakiani,Valentina Boscaro,Enzo Medico,Martin R. Weiser,Salvatore Siena,Federica Di Nicolantonio,David B. Solit,Alberto Bardelli +25 more
TL;DR: KRAS mutations are identified as frequent drivers of acquired resistance to cetuximab in colorectal cancers, indicate that the emergence of KRAS mutant clones can be detected non-invasively months before radiographic progression and suggest early initiation of a MEK inhibitor as a rational strategy for delaying or reversing drug resistance.
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Classifying and valuing ecosystem services for urban planning
TL;DR: In this paper, the authors synthesize knowledge and methods to classify and value ecosystem services for urban planning and identify analytical challenges for valuation to inform urban planning in the face of high heterogeneity and fragmentation characterizing urban ecosystems.
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
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Economic valuation and the commodification of ecosystem services
TL;DR: In the last decade, a growing number of environmental scientists have advocated economic valuation of ecosystem services as a pragmatic short-term strategy to communicate the value of biodiversity and the importance of ecosystems.
Book ChapterDOI
Urban Ecosystem Services
Erik Gómez-Baggethun,Åsa Gren,David N. Barton,Johannes Langemeyer,Timon McPhearson,Patrick J. O’Farrell,Erik Andersson,Zoé A. Hamstead,Peleg Kremer +8 more
TL;DR: In this paper, the authors explore the potential of urban ecosystem services for improving resilience and quality of life in cities and describe a range of valuation approaches (cultural values, health benefits, economic costs, and resilience) for capturing the importance of urban ecosystems.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.
J. Guillermo Paez,Pasi A. Jänne,Pasi A. Jänne,Jeffrey C. Lee,Sean Tracy,Heidi Greulich,Heidi Greulich,Stacey Gabriel,Paula Herman,Frederic J. Kaye,Neal I. Lindeman,Titus J. Boggon,Katsuhiko Naoki,Hidefumini Sasaki,Yoshitaka Fujii,Michael J. Eck,William R. Sellers,William R. Sellers,William R. Sellers,Bruce E. Johnson,Bruce E. Johnson,Matthew Meyerson,Matthew Meyerson +22 more
TL;DR: Results suggest that EGFR mutations may predict sensitivity to gefitinib, and treatment with the EGFR kinase inhibitor gefitsinib causes tumor regression in some patients with NSCLC, more frequently in Japan.
Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
Journal ArticleDOI
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
TL;DR: This Review summarizes the current understanding of the mechanistic aspects of microRNA-induced repression of translation and discusses some of the controversies regarding different modes of micro RNA function.
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