Regulation of stearoyl-coa desaturase by polyunsaturated fatty acids and cholesterol
TLDR
The goal of this review is to provide an overview of the genetic regulation of the stearoyl-CoA desaturase in response to dietary polyunsaturated fatty acids and cholesterol.About:
This article is published in Journal of Lipid Research.The article was published on 1999-09-01 and is currently open access. It has received 758 citations till now. The article focuses on the topics: Stearoyl-CoA desaturase-1 & Polyunsaturated fatty acid.read more
Citations
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Journal ArticleDOI
Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity
James M. Ntambi,Makoto Miyazaki,Jonathan P. Stoehr,Hong Lan,Christina Kendziorski,Brian S. Yandell,Yang Song,Paul Cohen,Jeffrey M. Friedman,Alan D. Attie +9 more
TL;DR: It is shown that mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased insulin sensitivity, and are resistant to diet-induced weight gain, suggesting that a consequence ofSCD1 deficiency is an activation of lipid oxidation in addition to reduced triglyceride synthesis and storage.
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Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Delta(9)-desaturase.
J. M. Griinari,Benjamin A. Corl,Shannon H. Lacy,P. Y. Chouinard,K. V. V. Nurmela,Dale E. Bauman +5 more
TL;DR: Results demonstrate that endogenous synthesis of CLA from trans-11 18:1 represented the primary source of CLA in milk fat of lactating cows.
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Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
Haiming Cao,Kristin A. Gerhold,Jared R. Mayers,Michelle M. Wiest,Steven M. Watkins,Gökhan S. Hotamisligil +5 more
TL;DR: It is demonstrated that adipose tissue uses lipokines such as C16:1n7-palmitoleate to communicate with distant organs and regulate systemic metabolic homeostasis and a lipid-mediated endocrine network is revealed.
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Structure, function, and dietary regulation of δ6, δ5, and δ9 desaturases
TL;DR: Delta-6 and Δ5 desaturases are required for the synthesis of highly unsaturated fatty acids (HUFAs), which are mainly esterified into phospholipids and contribute to maintaining membrane fluidity, and may be required for cold tolerance in plants and fish.
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Enzymes of triacylglycerol synthesis and their regulation
TL;DR: De novo biosynthesis of triacylglycerol in eukaryotic cells, the isoenzymes that are involved, their subcellular locations, how they are regulated, and their putative individual roles in glycerolipid biosynthesis are focused on.
References
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The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
TL;DR: This research was supported by grants from the National Institutes of Health (HL20948) and the Perot Family Foundation.
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Membrane lipid composition and cellular function.
Arthur A. Spector,Mark A. Yorek +1 more
TL;DR: Membrane fatty acid composition, phospholipid composition, and cholesterol content can be modified in many different kinds of intact mammalian cells, and many of the functional responses probably are caused directly by the membrane lipid structural changes, which affect either bulk lipid fluidity or specific lipid domains.
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Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα
Daniel J. Peet,Stephen D. Turley,Wenzhen Ma,Bethany A. Janowski,Jean-Marc A. Lobaccaro,Robert E. Hammer,David J. Mangelsdorf +6 more
TL;DR: The existence of a physiologically significant feed-forward regulatory pathway for sterol metabolism and the role of LXR alpha as the major sensor of dietary cholesterol are established.
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Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway
Jürgen M. Lehmann,Steven A. Kliewer,Linda B. Moore,Tracey Smith-Oliver,Beverly B. Oliver,Jui Lan Su,Scott S. Sundseth,Deborah A. Winegar,Daniel E. Blanchard,Thomas A. Spencer,Timothy M. Willson +10 more
TL;DR: The data provide evidence for a new hormonal signaling pathway that activates transcription in response to oxysterols and suggest that LXRs play a critical role in the regulation of cholesterol homeostasis.
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SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
TL;DR: Sterol-regulated proteolysis of a membrane-bound transcription factor provides a novel mechanism by which transcription can be regulated by membrane lipids.