Regulation of stress response on the hypothalamic-pituitary-gonadal axis via gonadotropin-inhibitory hormone
TLDR
In this paper , the effects of various stressors, such as restraint, nutritional/metabolic and social stress, on gonadotropin-inhibitory hormone (GnIH) expression and/or its neuronal activity leading to altered hypothalamic-pituitary-gonadal (HPG) action are discussed.About:
This article is published in Frontiers in Neuroendocrinology.The article was published on 2022-01-01 and is currently open access. It has received 18 citations till now. The article focuses on the topics: Hypothalamic–pituitary–gonadal axis & Internal medicine.read more
Citations
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An evolutionary perspective on stress responses, damage and repair
Barbara Taborsky,Bram Kuijper,Tim W. Fawcett,Sinead English,Olof Leimar,John M. McNamara,Suvi Ruuskanen +6 more
TL;DR: In this paper , the authors studied the evolution of hormone levels as a function of stressor occurrence, damage and the efficiency of repair, and found that for higher repair rates, baseline and peak hormone levels are higher.
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Nutritional Risk Factors Associated with Vasomotor Symptoms in Women Aged 40–65 Years
Alexandra Tijerina,Yamile Barrera,Elizabeth Solís-Pérez,Rogelio Salas,José L. C. Jasso,Verónica López,Erik Ramírez,Rosario Pastor,Josep A. Tur,Cristina Bouzas +9 more
TL;DR: The presence of VMS was associated with different nutritional risk factors (weight, fasting glucose levels, cardiorespiratory fitness, and tobacco use) in women living in the northeast of Mexico in a retrospective way.
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The impact of chronic stress on the PFC transcriptome: a bioinformatic meta-analysis of publicly available RNA-sequencing datasets
TL;DR: A bioinformatic meta-analysis of publicly available RNA sequencing datasets was carried out to identify core PFC transcriptional signatures that underpin behavioral phenotypes including resilience and susceptibility and revealed that susceptibility genes were most affected in oligodendrocytes and linked to mechanisms which mediate biochemical, bidirectional communication between this cell-type and myelinated axons.
Journal ArticleDOI
Editorial: Stress and reproduction in animal models
TL;DR: In this article , the authors detected 37,470 novel circRNAs in the thyroid gland under different photoperiods, and performed functional enrichment annotation analysis with inositol phosphate metabolism, cGMP-PKG, calcium, MAPK signaling pathways.
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Putative Role of the Kisspeptin/Kiss1R System in Promoting Hypothalamic GnRH Release, Pubertal Maturation, and Regulation of Ovulation Considering the Central Reproductive Axis
TL;DR: Kisspeptin is a class of neuropeptides that are the product of the Kiss1 gene as mentioned in this paper , which plays an important role in maintaining gonadotropin-releasing hormone (GnRH) levels and their release through hypothalamic neurons.
References
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Journal ArticleDOI
The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
Journal ArticleDOI
Stress and the brain: from adaptation to disease
TL;DR: In response to stress, the brain activates several neuropeptide-secreting systems, which eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators as mentioned in this paper.
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Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions
TL;DR: It is proposed that stress-induced increases in glucocorticoid levels protect not against the source of stress itself but rather against the body's normal reactions to stress, preventing those reactions from overshooting and themselves threatening homeostasis.
Journal ArticleDOI
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more
TL;DR: Puberty is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus, and complementary genetic approaches in humans and mice identified genetic factors that determine the onset of puberty.
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Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
Nicolas de Roux,Emmanuelle Génin,Jean Claude Carel,Fumihiko Matsuda,Chaussain Jl,Edwin Milgrom +5 more
TL;DR: The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR 54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis.
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