Journal ArticleDOI
Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review.
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TLDR
Recent advances in the post-translational modification (PTMs) of signaling molecules and epigenetic modification of gene expression programs are summarized, critical for orchestrating IFN-mediated host immune response to the complex pathogenic or environmental stimuli.About:
This article is published in Journal of Autoimmunity.The article was published on 2017-09-01. It has received 184 citations till now. The article focuses on the topics: Cell signaling & Signal transduction.read more
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Decoding type I and III interferon signalling during viral infection.
TL;DR: Some of the advances that have been made towards understanding the complexity of differential interferon (IFN) signalling inputs and outputs as well as some of the strategies viruses use to interfere with or circumvent IFN-induced antiviral responses are highlighted.
Journal ArticleDOI
Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD.
Daniel Garcia,Kristina Hellberg,Amandine Chaix,Martina Wallace,Sébastien Herzig,Mehmet G. Badur,Terry Lin,Maxim N. Shokhirev,Antonio Pinto,Debbie S. Ross,Alan Saghatelian,Satchidananda Panda,Lukas E. Dow,Christian M. Metallo,Reuben J. Shaw +14 more
TL;DR: It is shown that liver-specific AMPK activation reprograms lipid metabolism, reduces liver steatosis, decreases expression of inflammation and fibrosis genes, and leads to significant therapeutic benefits in the context of diet-induced obesity, support AMPK as a target for the prevention and treatment of NAFLD.
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Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance.
TL;DR: In this paper, the authors review available evidence supporting the involvement of type I interferon (IFN) signaling in mediating resistance to various cancer therapies and highlight the most promising modalities that are being tested to overcome resistance.
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Interferon Lambda Genetics and Biology in Regulation of Viral Control.
TL;DR: The current understanding of type III IFNs is discussed, and how their functions are similar to, and different from, type I IFN in various immune cell subtypes and viral infections are discussed.
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Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism
TL;DR: This review aims to provide new insight into the understanding the complexity of the interplay between JAK/STAT signaling and viral antagonism, and the potential pathogenesis roles of tyrosine phosphorylation-independent non-canonical STATs activation during virus infection.
References
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Journal ArticleDOI
Regulation of microRNA biogenesis
Minju Ha,V. Narry Kim +1 more
TL;DR: Small non-coding RNAs that function as guide molecules in RNA silencing are involved in nearly all developmental and pathological processes in animals and their dysregulation is associated with many human diseases.
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Mechanisms of type-I- and type-II-interferon-mediated signalling.
TL;DR: It is anticipated that an increased understanding of the contributions of these recently identified pathways will advance current thinking about how interferons work.
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Virus interference. I The interferon
Alick Isaacs,Jean Lindenmann +1 more
TL;DR: During a study of the interference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorio-allantoic membrane it was found that following incubation of heated virus with membrane a new factor was released.
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STATs: transcriptional control and biological impact
David E. Levy,James E. Darnell +1 more
TL;DR: The signal transducer and activator of transcription (STAT) proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways.
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Interferon-Stimulated Genes: A Complex Web of Host Defenses
TL;DR: This review begins by introducing interferon (IFN) and the JAK-STAT signaling pathway to highlight features that impact ISG production and describes ways in which ISGs both enhance innate pathogen-sensing capabilities and negatively regulate signaling through the Jak-STAT pathway.