Journal ArticleDOI
The airway epithelium in asthma
Bart N. Lambrecht,Hamida Hammad +1 more
TLDR
Improved understanding of the epithelium's function in maintaining the integrity of the airways and its dysfunction in asthma has provided important mechanistic insight into how asthma is initiated and perpetuated and could provide a framework by which to select new therapeutic strategies that prevent exacerbations and alter the natural course of the disease.Abstract:
Asthma is a T lymphocyte-controlled disease of the airway wall caused by inflammation, overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity and airway obstruction. The airway epithelium is considered an essential controller of inflammatory, immune and regenerative responses to allergens, viruses and environmental pollutants that contribute to asthma pathogenesis. Epithelial cells express pattern recognition receptors that detect environmental stimuli and secrete endogenous danger signals, thereby activating dendritic cells and bridging innate and adaptive immunity. Improved understanding of the epithelium's function in maintaining the integrity of the airways and its dysfunction in asthma has provided important mechanistic insight into how asthma is initiated and perpetuated and could provide a framework by which to select new therapeutic strategies that prevent exacerbations and alter the natural course of the disease.read more
Citations
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Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
TL;DR: Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.
Journal ArticleDOI
International Consensus Statement on Allergy and Rhinology: Rhinosinusitis.
Richard R. Orlandi,Todd T. Kingdom,Peter H. Hwang,Tim Smith,Jeremiah A. Alt,Fuad M. Baroody,Pete S. Batra,Manuel Bernal-Sprekelsen,Neil Bhattacharyya,Rakesh K. Chandra,Alexander G. Chiu,Martin J. Citardi,Noam A. Cohen,John M. DelGaudio,Martin Desrosiers,Hun Jong Dhong,Richard G. Douglas,Berrylin J. Ferguson,Wytske Fokkens,Christos Georgalas,Andrew N. Goldberg,Jan Gosepath,Daniel L. Hamilos,Joseph K. Han,Richard J. Harvey,Peter Hellings,Claire Hopkins,Roger Jankowski,Amin R. Javer,Robert C. Kern,Stilianos E. Kountakis,Marek L. Kowalski,Andrew P. Lane,Donald C. Lanza,Richard A. Lebowitz,Heung Man Lee,Sandra Y. Lin,Valerie J. Lund,Amber U Luong,Wolf Mann,Bradley F. Marple,Kevin C. McMains,Ralph Metson,Robert M. Naclerio,Jayakar V. Nayak,Nobuyoshi Otori,James N. Palmer,Sanjay R. Parikh,Desiderio Passali,Anju T. Peters,Jay F. Piccirillo,David M. Poetker,Alkis J. Psaltis,Hassan H. Ramadan,Vijay R. Ramakrishnan,Herbert Riechelmann,Hwan Jung Roh,Luke Rudmik,Raymond Sacks,Rodney J. Schlosser,Brent A. Senior,Raj Sindwani,James A. Stankiewicz,Michael G. Stewart,Bruce K. Tan,Elina Toskala,Richard Louis Voegels,De Yun Wang,Erik K. Weitzel,Sarah K. Wise,Bradford A. Woodworth,Peter-John Wormald,Erin D. Wright,Bing Zhou,David W. Kennedy +74 more
TL;DR: This dissertation aims to provide a history of Chinese medical practice in the United States from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “modern China” began to circulate.
Journal ArticleDOI
Barrier Epithelial Cells and the Control of Type 2 Immunity
TL;DR: The general mechanisms of how different stimuli trigger type-2-cell-mediated immunity at mucosal barriers are reviewed and how this leads to protection or disease are reviewed.
Journal ArticleDOI
Respiratory epithelial cells orchestrate pulmonary innate immunity
TL;DR: The biophysical nature of pulmonary host defenses are integrated with the ability of respiratory epithelial cells to respond to and 'instruct' the professional immune system to protect the lungs from infection and injury.
Journal ArticleDOI
The Cytokines of Asthma
TL;DR: The cytokine networks driving asthma are reviewed, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic, to argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill,See Heng Wong,Agustin Bellosi,Robin J. Flynn,Maria Daly,Theresa K. A. Langford,Christine Bucks,Colleen M. Kane,Padraic G. Fallon,Richard Pannell,Helen E. Jolin,Andrew N.J. McKenzie +11 more
TL;DR: The identification and functional characterization of a new innate type-2 immune effector leukocyte that is named the nuocyte is presented, which represents a critically important innate effector cell in type- 2 immunity.