Journal ArticleDOI
Restless legs syndrome probably induced by risperidone treatment.
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TLDR
Symptoms typical of RLS may be induced by risperidone treatment and should be differentiated from akathisia, using polysomnography to objectify sleep disturbances and associated periodic leg movements during sleep (PLMS).Abstract:
Background: According to some reports, patients treated with risperidone may develop akathisia. Restless legs syndrome (RLS), which shares some clinical features with akathisia, is a distinct movement and sleep disorder that may be induced by various drugs that act on the CNS. Methods: We studied a 31-year-old patient suffering from a schizoaffective disorder including auditory hallucinations who developed symptoms typical of the RLS during treatment with risperidone, using polysomnography to objectify sleep disturbances and associated periodic leg movements during sleep (PLMS). Results: After switching from clozapine to risperidone treatment, the patient complained about dysethesias primarily of the legs, an urge to walk around, and sleep disturbances. The latter could be confirmed by polysomnography, including an abnormal PLMS index. Risperidone was switched to haloperidol. However, RLS symptoms were still present. After switching to quetiapine, RLS symptoms vanished and a second polysomnography test demonstrated better sleep quality and normal PLMS measurements. During the whole treatment period with different neuroleptics, the patient additionally received valproic acid. Conclusions: Symptoms typical of RLS may be induced by risperidone treatment and should be differentiated from akathisia. Although polysomnography is not necessary, it may be helpful confirming the diagnosis.read more
Citations
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Poor sleep as a potential causal factor in aggression and violence.
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Ropinirole is effective in the treatment of restless legs syndrome. TREAT RLS 2: A 12-week, double-blind, randomized, parallel-group, placebo-controlled study
Arthur S. Walters,William G. Ondo,Tilman Dreykluft,Ronald R. Grunstein,Daniel Lee,Kapil D. Sethi +5 more
TL;DR: Ropinirole improves symptoms, associated sleep disturbance, and QoL of RLS patients and is generally well tolerated.
Journal ArticleDOI
Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding.
Simon Cervenka,Sven Pålhagen,Robert A. Comley,Georgios Panagiotidis,Zsolt Cselényi,Julian C. Matthews,Robert Lai,Christer Halldin,Lars Farde +8 more
TL;DR: The study supports involvement of the dopamine system in both striatal and extrastriatal brain regions in the pathophysiology of RLS and shows the brain regions where differences in D2-receptor binding were shown are implicated in the regulation of affective and motivational aspects of sensory processing, suggesting a possible pathway for sensory symptoms in RLS.
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