Journal ArticleDOI
Review of the adipose derived stem cell secretome.
Sahil K. Kapur,Adam J. Katz +1 more
TLDR
More in depth studies that use uniform and standardized means of protein detection and analysis are necessary in light of the lack of uniformity in prior secretome-analysis studies, and the growing clinical importance of the ASC secretome.About:
This article is published in Biochimie.The article was published on 2013-12-01. It has received 262 citations till now.read more
Citations
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Journal ArticleDOI
The Current State of Fat Grafting: A Review of Harvesting, Processing, and Injection Techniques.
TL;DR: There has been a substantial increase in research interest to identify methodologies for optimizing fat graft survival, but despite some differences in harvest and implantation technique in the laboratory, these findings have not translated into a universal protocol for fat grafting.
Journal ArticleDOI
Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells - a review.
Lucie Bacakova,Jana Zarubova,Martina Trávníčková,Jana Musilkova,Julia Pajorova,Petr Slepička,Nikola Slepičková Kasálková,Václav Švorčík,Zdenka Kolska,Hooman Motarjemi,Martin Molitor +10 more
TL;DR: Adipose tissue-derived stem cells (ASCs) are considered highly promising in present-day regenerative medicine because of its abundancy, its subcutaneous location, and the need for less invasive techniques.
Journal ArticleDOI
Adipose stem cells: biology and clinical applications for tissue repair and regeneration.
TL;DR: The regenerative properties of ASCs that can be harnessed for clinical applications are discussed, current and future challenges for ASC clinical use are explored, and such challenges include knowledge-based deficiencies, hurdles for translating research to the clinic, and barriers to establishing a new paradigm of medical care.
Journal ArticleDOI
Procedure, applications, and outcomes of autologous fat grafting.
TL;DR: Lipofilling is a low-risk procedure that can be used to correct soft-tissue defects in the face, trunk, and extremities, with minimal discomfort for patients.
Journal ArticleDOI
Stimulating the Neurotrophic and Angiogenic Properties of Human Adipose-Derived Stem Cells Enhances Nerve Repair
TL;DR: Human adipose-derived stem cells produce functional neurotrophic and angiogenic factors, creating a more desirable microenvironment for nerve regeneration, and their effects in a peripheral nerve injury model were determined.
References
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Journal ArticleDOI
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
Journal ArticleDOI
Improved Prediction of Signal Peptides: SignalP 3.0
TL;DR: Improvements of the currently most popular method for prediction of classically secreted proteins, SignalP, which consists of two different predictors based on neural network and hidden Markov model algorithms, where both components have been updated.
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Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
Jalees Rehman,Dmitry O. Traktuev,Jingling Li,Stephanie Merfeld-Clauss,Constance J. Temm-Grove,Jason E. Bovenkerk,Carrie L. Pell,Brian H. Johnstone,Robert V. Considine,Keith L. March +9 more
TL;DR: The findings suggest that autologous delivery of either native or transduced subcutaneous ASCs, which are regulated by hypoxia, may be a novel therapeutic option to enhance angiogenesis or achieve cardiovascular protection.
Journal ArticleDOI
Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: A joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT)
Philippe Bourin,Bruce A. Bunnell,Louis Casteilla,Massimo Dominici,Adam J. Katz,Keith L. March,Heinz Redl,J. Peter Rubin,Kotaro Yoshimura,Jeffrey M. Gimble +9 more
TL;DR: The goal of this paper is to provide initial guidance for the scientific community working with adipose-derived cells and to facilitate development of international standards based on reproducible parameters.
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Feature-based prediction of non-classical and leaderless protein secretion.
TL;DR: By scanning the entire human proteome, a sequence-based method, SecretomeP, is presented, it is discovered that certain pathway-independent features are shared among secreted proteins.