Journal ArticleDOI
Risk factors and outcomes of maternal obesity and excessive weight gain during pregnancy
Romy Gaillard,Büşra Durmuş,Albert Hofman,Johan P. Mackenbach,Eric A. P. Steegers,Vincent W. V. Jaddoe +5 more
TLDR
The prevalence of overweight and obesity among women of reproductive age is increasing and risk factors and maternal, fetal and childhood consequences of maternal obesity and excessive gestational weight gain are determined.Abstract:
Objective:
The prevalence of overweight and obesity among women of reproductive age is increasing. We aimed to determine risk factors and maternal, fetal and childhood consequences of maternal obesity and excessive gestational weight gain.
Design and Methods:
The study was embedded in a population-based prospective cohort study among 6959 mothers and their children. The study was based in Rotterdam, The Netherlands (2001–2005).
Results:
Maternal lower educational level, lower household income, multiparity, and FTO risk allel were associated with an increased risk of maternal obesity, whereas maternal European ethnicity, nulliparity, higher total energy intake, and smoking during pregnancy were associated with an increased risk of excessive gestational weight gain (all p-values <0.05). As compared to normal weight, maternal obesity was associated with increased risks of gestational hypertension (OR 6.31 (95% CI 4.30, 9.26)), preeclampsia (OR (3.61, (95% CI 2.04, 6.39)), gestational diabetes (OR 6.28 (95%CI 3.01, 13.06)), caesarean delivery (OR 1.91 (95% CI 1.46, 2.50)), delivering large size for gestational age infants (OR 2.97 (95% CI 2.16, 4.08)), and childhood obesity (OR 5.02 (95% CI:2.97, 8.45)). Weaker associations of excessive gestational weight gain with maternal, fetal and childhood outcomes were observed, with the strongest effects for first trimester weight gain.
Conclusions:
Our study shows that maternal obesity and excessive weight gain during pregnancy are associated with socio-demographic, lifestyle, and genetic factors and with increased risks of adverse maternal, fetal and childhood outcomes. As compared to prepregnancy overweight and obesity, excessive gestational weight gain has a limited influence on adverse pregnancy outcomes.read more
Citations
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Journal ArticleDOI
Risk Factors for Childhood Obesity in the First 1,000 Days: A Systematic Review.
Jennifer A. Woo Baidal,Jennifer A. Woo Baidal,Lindsey M. Locks,Erika R. Cheng,Tiffany Blake-Lamb,Tiffany Blake-Lamb,Meghan Perkins,Elsie M. Taveras +7 more
TL;DR: Several risk factors during the first 1,000 days were consistently associated with later childhood obesity, and can inform future research and policy priorities and intervention efforts to prevent childhood obesity.
Journal ArticleDOI
Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies
TL;DR: A practical evidence based list of clinical risk factors that can be assessed by a clinician at ≤16 weeks’ gestation to estimate a woman’s risk of pre-eclampsia and the use of aspirin prophylaxis in pregnancy is developed.
Obesity as an independent risk factor for elective and emergency caesarean delivery in nulliparous women – Systematic review.
TL;DR: The objective of the study was to investigate the association between increasing maternal body mass index (BMI) and elective/emergency caesarean delivery rates and systematic review and meta‐analysis of published cohort studies were used.
Journal ArticleDOI
Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts
Susana Santos,Ellis Voerman,Pilar Amiano,Henrique Barros,Lawrence J. Beilin,Anna Bergström,Marie-Aline Charles,Leda Chatzi,Cécile Chevrier,George P. Chrousos,Eva Corpeleijn,Olga Costa,Nathalie Costet,Sarah Crozier,Graham Devereux,Myriam Doyon,Merete Eggesbø,Maria Pia Fantini,Sara Farchi,Francesco Forastiere,Vagelis Georgiu,Keith M. Godfrey,Davide Gori,Veit Grote,Wojciech Hanke,Irva Hertz-Picciotto,Barbara Heude,Marie-France Hivert,Daniel O. Hryhorczuk,Rae-Chi Huang,Hazel Inskip,Anne M. Karvonen,Louise C. Kenny,Berthold Koletzko,Leanne K. Küpers,Hanna Lagström,Irina Lehmann,Per Magnus,Renata Majewska,Johanna Mäkelä,Yannis Manios,Fionnuala M. McAuliffe,Sheila McDonald,John Mehegan,Erik Melén,Monique Mommers,Camilla Schmidt Morgen,George Moschonis,Deirdre M. Murray,Carol Ní Chaoimh,Ellen A. Nohr,Anne-Marie Nybo Andersen,Emily Oken,Adriëtte J J M Oostvogels,Agnieszka Pac,Eleni Papadopoulou,Juha Pekkanen,Costanza Pizzi,Kinga Polańska,Daniela Porta,Lorenzo Richiardi,Sheryl L. Rifas-Shiman,Nel Roeleveld,Luca Ronfani,Ana Cristina Santos,Marie Standl,Hein Stigum,Camilla Stoltenberg,Elisabeth Thiering,Carel Thijs,Maties Torrent,Suzanne Tough,Tomas Trnovec,Steve Turner,Marleen M.H.J. van Gelder,Lenie van Rossem,Andrea von Berg,Martine Vrijheid,Tanja G. M. Vrijkotte,Jane West,Alet H. Wijga,John Wright,Oleksandr Zvinchuk,Thorkild I. A. Sørensen,Debbie A Lawlor,Romy Gaillard,Vincent W. V. Jaddoe,Vincent W. V. Jaddoe +87 more
TL;DR: In this paper, the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact were assessed.
References
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Journal ArticleDOI
Establishing a standard definition for child overweight and obesity worldwide: international survey
TL;DR: The proposed cut off points, which are less arbitrary and more internationally based than current alternatives, should help to provide internationally comparable prevalence rates of overweight and obesity in children.
Journal ArticleDOI
Variation in FTO contributes to childhood obesity and severe adult obesity
Christian Dina,David Meyre,Sophie Gallina,Emmanuelle Durand,Antje Körner,Peter Jacobson,Lena M. S. Carlsson,Wieland Kiess,Vincent Vatin,Cécile Lecoeur,Jérôme Delplanque,Emmanuel Vaillant,François Pattou,Juan Ruiz,Jacques Weill,Claire Levy-Marchal,Fritz F. Horber,Natascha Potoczna,Serge Hercberg,Catherine Le Stunff,Pierre Bougnères,Peter Kovacs,Michel Marre,Beverley Balkau,Beverley Balkau,Stéphane Cauchi,Jean-Claude Chèvre,Philippe Froguel,Philippe Froguel +28 more
TL;DR: It is concluded that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
Journal ArticleDOI
Obesity, obstetric complications and cesarean delivery rate--a population-based screening study.
Joshua L Weiss,Fergal D. Malone,Danielle Emig,Robert H. Ball,David A. Nyberg,Christine H. Comstock,George R. Saade,Keith Eddleman,Suzanne M. Carter,Sabrina D. Craigo,Stephen R. Carr,Mary E. D'Alton +11 more
TL;DR: Obesity is an independent risk factor for adverse obstetric outcome and is significantly associated with an increased cesarean delivery rate.
Journal ArticleDOI
The Generation R Study: design and cohort update 2010
Vincent W. V. Jaddoe,Cock M. van Duijn,Albert J. van der Heijden,Johan P. Mackenbach,Henriëtte A. Moll,Eric A.P. Steegers,Henning Tiemeier,André G. Uitterlinden,Frank C. Verhulst,Albert Hofman +9 more
TL;DR: The Generation R Study is a population-based prospective cohort study designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood.
Journal ArticleDOI
Maternal Obesity and Risk of Gestational Diabetes Mellitus
Susan Y. Chu,William M. Callaghan,Shin Y. Kim,Christopher H. Schmid,Joseph Lau,Lucinda J. England,Patricia M. Dietz +6 more
TL;DR: In this paper, a meta-analysis was conducted to better estimate the risk of gestational diabetes mellitus (GDM) among women who are overweight or obese compared with lean or normal-weight women.